A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

Bcl-2 inhibits apoptosis by two distinct mechanisms but only one is targeted to treat Bcl-2-positive malignancies. In this mechanism, the BH1-3 domains of Bcl-2 form a hydrophobic pocket, binding and inhibiting pro-apoptotic proteins, including Bim. In the other mechanism, the BH4 domain mediates in...

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Detalles Bibliográficos
Autores principales: Lavik, Andrew R., Zhong, Fei, Chang, Ming-Jin, Greenberg, Edward, Choudhary, Yuvraj, Smith, Mitchell R., McColl, Karen S., Pink, John, Reu, Frederic J., Matsuyama, Shigemi, Distelhorst, Clark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694997/
https://www.ncbi.nlm.nih.gov/pubmed/26317541

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