Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

Previous studies suggest the anti-inflammatory drug, sulindac inhibits tumorigenesis by a COX independent mechanism involving cGMP PDE inhibition. Here we report that the cGMP PDE isozymes, PDE5 and 10, are elevated in colon tumor cells compared with normal colonocytes, and that inhibitors and siRNA...

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Detalles Bibliográficos
Autores principales: Li, Nan, Chen, Xi, Zhu, Bing, Ramírez-Alcántara, Verónica, Canzoneri, Joshua C., Lee, Kevin, Sigler, Sara, Gary, Bernard, Li, Yonghe, Zhang, Wei, Moyer, Mary P., Salter, E. Alan, Wierzbicki, Andrzej, Keeton, Adam B., Piazza, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694998/
https://www.ncbi.nlm.nih.gov/pubmed/26299804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694998/
https://www.ncbi.nlm.nih.gov/pubmed/26299804

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