Cargando…

IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and dna repair associated molecules

Cisplatin-based chemotherapy is currently the most effective treatment regimen for non-small cell lung cancer (NSCLC), but eventually tumor resistance develops which limits its success. The potential implication of IL-6 signaling in the cisplatin resistance of NSCLC was explored by testing whether N...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duan, Shanzhou, Tsai, Ying, Keng, Peter, Chen, Yongbing, Lee, Soo Ok, Chen, Yuhchyau
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695015/ https://www.ncbi.nlm.nih.gov/pubmed/26313152

Ejemplares similares

Cisplatin treatment increases stemness through upregulation of hypoxia‐inducible factors by interleukin‐6 in non‐small cell lung cancer
por: Zhang, Fuquan, et al.
Publicado: (2016)

IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer
por: Lee, Soo Ok, et al.
Publicado: (2015)

IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation
por: Chen, Yuhchyau, et al.
Publicado: (2015)

Retraction Note to: IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation
por: Chen, Yuhchyau, et al.
Publicado: (2022)

A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer
por: Yang, Li, et al.
Publicado: (2016)

Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells
por: Shen, Mingjing, et al.
Publicado: (2020)

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway
por: Shen, Ming Jing, et al.
Publicado: (2017)

Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition
por: Yang, Li, et al.
Publicado: (2017)

Inhibition of IL‐6‐JAK/Stat3 signaling in castration‐resistant prostate cancer cells enhances the NK cell‐mediated cytotoxicity via alteration of PD‐L1/NKG2D ligand levels
por: Xu, LiJun, et al.
Publicado: (2018)

MiR-940 inhibits TGF-β-induced epithelial-mesenchymal transition and cell invasion by targeting Snail in non-small cell lung cancer
por: Jiang, Kanqiu, et al.
Publicado: (2019)

Correction: MiR-940 inhibits TGF-β-induced epithelial-mesenchymal transition and cell invasion by targeting Snail in non-small cell lung cancer
por: Jiang, Kanqiu, et al.
Publicado: (2020)

Log odds of positive lymph nodes is a robust predictor of survival and benefits from postoperative radiotherapy in stage IIIA‐N2 resected non‐small cell lung cancer
por: Jin, Xing, et al.
Publicado: (2022)

Biodegradable Nanoparticles Mediated Co-delivery of Erlotinib (ELTN) and Fedratinib (FDTN) Toward the Treatment of ELTN-Resistant Non-small Cell Lung Cancer (NSCLC) via Suppression of the JAK2/STAT3 Signaling Pathway
por: Chen, Donglai, et al.
Publicado: (2018)

ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer
por: Kim, Eun Young, et al.
Publicado: (2017)

Treatment of clinical T4 stage superior sulcus non-small cell lung cancer: a propensity-matched analysis of the surveillance, epidemiology, and end results database
por: Wen, Junmiao, et al.
Publicado: (2019)

Surgical treatment of an esophageal bronchogenic cyst with massive upper digestive tract hematoma without esophagectomy: a case report and the review of the literature
por: Cheng, Yuanjun, et al.
Publicado: (2018)

Learning curve for uniportal video-assisted thoracoscopic anatomical segmentectomy
por: Chen, Lei, et al.
Publicado: (2022)

Macrophage-targeting gene silencing orchestrates myocardial microenvironment remodeling toward the anti-inflammatory treatment of ischemia-reperfusion (IR) injury
por: Wang, Yao, et al.
Publicado: (2022)

Identification of epithelial-mesenchymal transition-related biomarkers in lung adenocarcinoma using bioinformatics and lab experiments
por: Cheng, Yuanjun, et al.
Publicado: (2023)

Prognostic impact of pretreatment lymphocyte-to-monocyte ratio in advanced epithelial cancers: a meta-analysis
por: Mao, Yiming, et al.
Publicado: (2018)

Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cells
por: Kurata, M, et al.
Publicado: (2011)

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells
por: Arora, Sanjeevani, et al.
Publicado: (2016)

Relationship between stromal cells and tumor spread through air spaces in lung adenocarcinoma
por: Qiu, Xie, et al.
Publicado: (2019)

Computational modeling of apoptotic signaling pathways induced by cisplatin
por: Hong, Ji-Young, et al.
Publicado: (2012)

Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis
por: Liu, Yangyang, et al.
Publicado: (2021)

Clinical implications and molecular features of tertiary lymphoid structures in stage I lung adenocarcinoma
por: Xu, Xuejun, et al.
Publicado: (2023)

Role of Nucleotide Excision Repair in Cisplatin Resistance
por: Duan, Mingrui, et al.
Publicado: (2020)

The small molecule STF-62247 induces apoptotic and autophagic cell death in leukemic cells
por: Kozako, Tomohiro, et al.
Publicado: (2018)

TRIB2 contributes to cisplatin resistance in small cell lung cancer
por: Liang, Yuanxin, et al.
Publicado: (2017)

Is the result of modified Allen’s test still accurate after endoscopic thoracic sympathectomy?
por: Zhang, Jiaheng, et al.
Publicado: (2020)

Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells
por: Kang, Fu-Chi, et al.
Publicado: (2015)

Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells
por: Lee, Chiu-Fang, et al.
Publicado: (2018)

Overexpression of IL-7 enhances cisplatin resistance in glioma
por: Cui, Lei, et al.
Publicado: (2012)

A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC
por: Dean, E J, et al.
Publicado: (2010)

EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis
por: Fan, Chi-Chen, et al.
Publicado: (2020)

Plants and Small Molecules: An Up-and-Coming Synergy
por: Lepri, A., et al.
Publicado: (2023)

GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells
por: Subhash, Vinod Vijay, et al.
Publicado: (2015)

Small molecules in the treatment of COVID-19
por: Lei, Sibei, et al.
Publicado: (2022)

Neuronal repair: Apoptotic proteins make good
por: Reina, Christopher P., et al.
Publicado: (2013)

Effect of erlotinib combined with cisplatin on IL-6 and IL-12 in mice with Lewis lung cancer
por: Zhang, Xu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2u185irmupbu7m7t84e2h3321k