Cargando…

Na(+)/K(+)-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma

We aimed to identify the expression patterns of Na(+)/K(+)-ATPase (NKA) α subunits in human hepatocellular carcinoma (HCC) samples and evaluate these subunits as potential targets for HCC treatment. The mRNA expression profiles of NKA α subunits in human HCC samples were analyzed. We found that the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhuang, Liping, Xu, Litao, Wang, Peng, Jiang, Yan, Yong, Pan, Zhang, Chenyue, Zhang, Haibin, Meng, Zhiqiang, Yang, Peiying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695053/ https://www.ncbi.nlm.nih.gov/pubmed/26334094

Ejemplares similares

β subunit affects Na(+) and K(+) affinities of Na(+)/K(+)-ATPase: Na(+) and K(+) affinities of a hybrid Na(+)/K(+)-ATPase composed of insect α and mammalian β subunits
por: Homareda, Haruo, et al.
Publicado: (2022)

Tuning of the Na,K-ATPase by the beta subunit
por: Hilbers, Florian, et al.
Publicado: (2016)

Transcriptional regulators of Na,K-ATPase subunits
por: Li, Zhiqin, et al.
Publicado: (2015)

Flexible selection of diversified Na(+)/K(+)-ATPase α-subunit isoforms for osmoregulation in teleosts
por: Wong, Marty Kwok-Shing, et al.
Publicado: (2016)

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells
por: Yan, Yanling, et al.
Publicado: (2016)

The β Subunit of the Na(+)/K(+)-ATPase Follows the Conformational State of the Holoenzyme
por: Dempski, Robert E., et al.
Publicado: (2005)

Regulation of Cardiac Contractility by the Alpha 2 Subunit of the Na(+)/K(+)-ATPase
por: Skogestad, Jonas, et al.
Publicado: (2022)

The Na(+), K(+)-ATPase β1 subunit regulates epithelial tight junctions via MRCKα
por: Bai, Haiqing, et al.
Publicado: (2021)

The Role of Na,k-Atpase α Subunit Serine 775 and Glutamate 779 in Determining the Extracellular K(+)And Membrane Potential–Dependent Properties of the Na,k -Pump
por: Peluffo, R. Daniel, et al.
Publicado: (2000)

Anti–Na(+)/K(+)-ATPase immunotherapy ameliorates α-synuclein pathology through activation of Na(+)/K(+)-ATPase α1–dependent autophagy
por: Cao, Lei, et al.
Publicado: (2021)

Access of Extracellular Cations to their Binding Sites in Na,K-ATPase: Role of the Second Extracellular Loop of the α Subunit
por: Capendeguy, Oihana, et al.
Publicado: (2006)

Basal Glutathionylation of Na,K-ATPase α-Subunit Depends on Redox Status of Cells during the Enzyme Biosynthesis
por: Mitkevich, Vladimir A., et al.
Publicado: (2016)

Evolution of the α-Subunit of Na/K-ATPase from Paramecium to Homo sapiens: Invariance of Transmembrane Helix Topology
por: Morrill, Gene A., et al.
Publicado: (2016)

Effect of Reduction of Redox Modifications of Cys-Residues in the Na,K-ATPase α1-Subunit on Its Activity
por: Dergousova, Elena A., et al.
Publicado: (2017)

Subcellular distribution of tissue kallikrein and Na,K-ATPase α-subunit in rat parotid striated duct cells
por: Simson, J. A. V., et al.
Publicado: (1994)

Na+/K+‑ATPase subunit α3 expression is associated with the efficacy of digitoxin treatment in pancreatic cancer cells
por: Lindholm, Heléne, et al.
Publicado: (2022)

Maturation of the catalytic alpha-subunit of Na,K-ATPase during intracellular transport
Publicado: (1987)

The Polarized Distribution of Na(+),K(+)-ATPase: Role of the Interaction between β Subunits
por: Padilla-Benavides, Teresita, et al.
Publicado: (2010)

Bioinformatics approaches for classification and investigation of the evolution of the Na/K-ATPase alpha-subunit
por: Shahnazari, Marzieh, et al.
Publicado: (2022)

Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway
por: Wang, Haiyong, et al.
Publicado: (2016)

Role of monocyte-to-lymphocyte ratio in predicting sorafenib response in patients with advanced hepatocellular carcinoma
por: Zhu, Zhenfeng, et al.
Publicado: (2018)

Na,K-ATPase α1 and β-subunits show distinct localizations in the nervous tissue of the large milkweed bug
por: Herbertz, Marlena, et al.
Publicado: (2022)

Na+/K+ ATPase α1 and β3 subunits are localized to the basolateral membrane of trophectoderm cells in human blastocysts
por: Hirakawa, T, et al.
Publicado: (2022)

Inhibition of K(+) Transport through Na(+), K(+)-ATPase by Capsazepine: Role of Membrane Span 10 of the α-Subunit in the Modulation of Ion Gating
por: Mahmmoud, Yasser A., et al.
Publicado: (2014)

Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma †
por: Udoh, Utibe-Abasi S., et al.
Publicado: (2022)

The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase
Publicado: (1990)

The Na, K-ATPase β-Subunit Isoforms Expression in Glioblastoma Multiforme: Moonlighting Roles
por: Rotoli, Deborah, et al.
Publicado: (2017)

Hyperpolarization-activated inward leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na(+)/K(+)-ATPase α subunit
por: Meier, Susan, et al.
Publicado: (2010)

SH2 Ligand-Like Effects of Second Cytosolic Domain of Na/K-ATPase α1 Subunit on Src Kinase
por: Banerjee, Moumita, et al.
Publicado: (2015)

Phosphorylation of Na(+),K(+)-ATPase at Tyr10 of the α1-Subunit is Suppressed by AMPK and Enhanced by Ouabain in Cultured Kidney Cells
por: Petrič, Metka, et al.
Publicado: (2021)

Hypoxia and HIF-1α Regulate the Activity and Expression of Na,K-ATPase Subunits in H9c2 Cardiomyoblasts
por: Gurler, Beyza, et al.
Publicado: (2023)

Prognostic nutritional index serves as a predictive marker of survival and associates with systemic inflammatory response in metastatic intrahepatic cholangiocarcinoma
por: Zhang, Chenyue, et al.
Publicado: (2016)

Serum liver enzymes serve as prognostic factors in patients with intrahepatic cholangiocarcinoma
por: Zhang, Chenyue, et al.
Publicado: (2017)

Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit
Publicado: (1996)

Expression and Trafficking of the γ Subunit of Na,K-ATPase in Hypertonically Challenged IMCD3 Cells
por: Pihakaski-Maunsbach, Kaarina, et al.
Publicado: (2008)

The alpha and beta subunits of the Na,K-ATPase can assemble at the plasma membrane into functional enzyme
Publicado: (1994)

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications
Publicado: (1987)

Localization of Na+,K+-ATPase alpha-subunit to the sinusoidal and lateral but not canalicular membranes of rat hepatocytes
Publicado: (1987)

The β(2)-Subunit (AMOG) of Human Na(+), K(+)-ATPase Is a Homophilic Adhesion Molecule
por: Roldán, María Luisa, et al.
Publicado: (2022)

Bioinformatic Analysis of Na(+), K(+)-ATPase Regulation through Phosphorylation of the Alpha-Subunit N-Terminus
por: Blayney, Emma-Lucille, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j13aelk1ov625d2q6im0gi7o3c