Cargando…

Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline

Circadian rhythm dysfunction and cognitive decline, specifically memory loss, frequently accompany natural aging. Circadian rhythms and memory are intertwined, as circadian rhythms influence memory formation and recall in young and old rodents. Although, the precise relationship between circadian rh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deibel, Scott H., Zelinski, Erin L., Keeley, Robin J., Kovalchuk, Olga, McDonald, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695111/ https://www.ncbi.nlm.nih.gov/pubmed/26252151

Ejemplares similares

Growth of malignant extracranial tumors alters microRNAome in the prefrontal cortex of TumorGraft mice
por: Kovalchuk, Anna, et al.
Publicado: (2017)

BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine
por: Kannan, Senthil, et al.
Publicado: (2015)

Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice
por: Sun, Junjun, et al.
Publicado: (2016)

Epigenetic clock analyses of cellular senescence and ageing
por: Lowe, Donna, et al.
Publicado: (2016)

Age-related decline in cardiac autonomic function is not attenuated with increased physical activity
por: Njemanze, Hugo, et al.
Publicado: (2016)

The potential role of epigenetic modulations in BPPV maneuver exercises
por: Tsai, Kun-Ling, et al.
Publicado: (2016)

The rate of change in declining steroid hormones: a new parameter of healthy aging in men?
por: Walther, Andreas, et al.
Publicado: (2016)

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus
por: Kim, Su-Jeong, et al.
Publicado: (2016)

Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration
por: Gao, Xu, et al.
Publicado: (2016)

Estrogen receptors involvement in intervertebral discogenic pain of the elderly women: colocalization and correlation with the expression of Substance P in nucleus pulposus
por: Song, Xiao-Xing, et al.
Publicado: (2017)

Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration
por: Elmasry, Khaled, et al.
Publicado: (2018)

Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development
por: Beheshti, Afshin, et al.
Publicado: (2015)

Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila
por: Wen, Deng-Tai, et al.
Publicado: (2017)

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions
por: Schütze, Sandra, et al.
Publicado: (2014)

Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift
por: Jylhävä, Juulia, et al.
Publicado: (2016)

Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells
por: Li, Cheng-Wei, et al.
Publicado: (2016)

Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium
por: Bajwa, Preety, et al.
Publicado: (2016)

Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk
por: Cheng, Jie, et al.
Publicado: (2017)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity
por: Stepanova, Maria, et al.
Publicado: (2015)

RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium
por: Park, Sung Wook, et al.
Publicado: (2015)

XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence
por: Heo, Jong-Ik, et al.
Publicado: (2016)

GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells
por: Park, Hyejin, et al.
Publicado: (2016)

Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFα
por: Sasaki, Norihiko, et al.
Publicado: (2017)

Aging is a weak but relentless determinant of dementia severity
por: Royall, Donald R., et al.
Publicado: (2016)

Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain
por: Gong, Huan, et al.
Publicado: (2015)

APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study
por: Iacono, Diego, et al.
Publicado: (2015)

The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice
por: Heppolette, Chantal A. A., et al.
Publicado: (2016)

Alzheimer disease research in the 21(st) century: past and current failures, new perspectives and funding priorities
por: Pistollato, Francesca, et al.
Publicado: (2016)

Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats
por: Lesovaya, Ekaterina A., et al.
Publicado: (2015)

Mitochondrial dysfunction and oxidative stress in aging and cancer
por: Kudryavtseva, Anna V., et al.
Publicado: (2016)

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease
por: Lesuis, Sylvie L., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_55k3gd9820rr16upbo1lp7nv0n