Cargando…

Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents

Docetaxel-based chemotherapy is established as a first-line treatment and standard of care for patients with metastatic castration-resistant prostate cancer. However, half of the patients do not respond to treatment and those do respond eventually become refractory. A better understanding of the res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Guanyi, Liu, Xichun, Li, Jianzhuo, Ledet, Elisa, Alvarez, Xavier, Qi, Yanfeng, Fu, Xueqi, Sartor, Oliver, Dong, Yan, Zhang, Haitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695123/ https://www.ncbi.nlm.nih.gov/pubmed/26160840

Ejemplares similares

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy
por: Cao, Bo, et al.
Publicado: (2014)

Racial Differences in Androgen Receptor (AR) and AR Splice Variants (AR-SVs) Expression in Treatment-Naïve Androgen-Dependent Prostate Cancer
por: Khan, Farhan, et al.
Publicado: (2023)

Regulation of androgen receptor splice variant AR3 by PCGEM1
por: Zhang, Ziqiang, et al.
Publicado: (2016)

AR Splicing Variants and Resistance to AR Targeting Agents
por: Kanayama, Mayuko, et al.
Publicado: (2021)

3D motion of vesicles along microtubules helps them to circumvent obstacles in cells
por: Verdeny-Vilanova, Ione, et al.
Publicado: (2017)

Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC)
por: Chandrasekaran, Balaji, et al.
Publicado: (2023)

Fecal microbiota transplantation: can it circumvent resistance to PD-1 blockade in melanoma?
por: Derosa, Lisa, et al.
Publicado: (2021)

Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities
por: Basil, Paul, et al.
Publicado: (2022)

Role of Circulating Tumor Cells (CTC), Androgen Receptor Full Length (AR-FL) and Androgen Receptor Splice Variant 7 (AR-V7) in a Prospective Cohort of Castration-Resistant Metastatic Prostate Cancer Patients
por: Cattrini, Carlo, et al.
Publicado: (2019)

Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells
por: Rana, Manjul, et al.
Publicado: (2021)

Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells
por: Shafi, Ayesha A., et al.
Publicado: (2015)

Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases
por: Kallio, Heini M. L., et al.
Publicado: (2018)

Circumventing the Greatwall
por: Short, Ben
Publicado: (2014)

Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
por: Claessens, Frank, et al.
Publicado: (2008)

Therapeutic targeting of the androgen receptor (AR) and AR variants in prostate cancer
por: Narayanan, Ramesh
Publicado: (2020)

A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8
por: Ashida, Hiroshi, et al.
Publicado: (2020)

Evaluation of the genomic alterations in the androgen receptor gene during treatment with high-dose testosterone for metastatic castrate-resistant prostate cancer
por: Moses, Marcus, et al.
Publicado: (2020)

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression
por: Li, Yingming, et al.
Publicado: (2012)

Author Correction: Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells
por: Rana, Manjul, et al.
Publicado: (2021)

Pathogenic/Likely Pathogenic Somatic CDK12 Mutations in Black Men With Prostate Cancer
por: Sartor, Oliver, et al.
Publicado: (2023)

Role of androgen receptor splice variant 7 (AR-V7) in prostate cancer resistance to 2(nd) generation androgen receptor signaling inhibitors
por: Zhu, Yezi, et al.
Publicado: (2020)

Identification of an AR Mutation-Negative Class of Androgen Insensitivity by Determining Endogenous AR Activity
por: Hornig, N. C., et al.
Publicado: (2016)

Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain
por: Hua, Yaping, et al.
Publicado: (2018)

Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling
por: Saxena, Neetu, et al.
Publicado: (2021)

PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer
por: Amante, Romain J., et al.
Publicado: (2023)

The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
por: Stockley, Jacqueline, et al.
Publicado: (2015)

Partial androgen insensitivity syndrome caused by a deep intronic mutation creating an alternative splice acceptor site of the AR gene
por: Ono, Hiroyuki, et al.
Publicado: (2018)

α-Mangostin Promotes In Vitro and In Vivo Degradation of Androgen Receptor and AR-V7 Splice Variant in Prostate Cancer Cells
por: Nauman, Mirielle C., et al.
Publicado: (2023)

Co-expression and clinical utility of AR-FL and AR splice variants AR-V3, AR-V7 and AR-V9 in prostate cancer
por: Wüstmann, Neele, et al.
Publicado: (2023)

SUN-LB136 A Comparison of Androgen Receptor Splice Variant, AR-V7, and Glucocorticoid Receptor Activity in Prostate Cancer
por: Dash, Amit K, et al.
Publicado: (2020)

S66. USING UNITIZATION TO CIRCUMVENT RELATIONAL MEMORY DEFICITS IN SCHIZOPHRENIA
por: de Sousa, Ana Elisa Farias, et al.
Publicado: (2020)

Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis
por: DePaolo, John S., et al.
Publicado: (2016)

Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction
por: Xu, Defeng, et al.
Publicado: (2017)

Inherited DNA-repair gene mutations in African American men with prostate cancer
por: Sartor, Oliver, et al.
Publicado: (2020)

Detection of androgen receptor (AR) and AR-V7 in small cell prostate carcinoma: Diagnostic and therapeutic implications
por: Zhao, Pei, et al.
Publicado: (2019)

Maximal androgen blockade for advanced prostate cancer
por: Mukha, Rajiv Paul, et al.
Publicado: (2010)

Duration of androgen deprivation therapy with maximum androgen blockade for localized prostate cancer
por: Fujimoto, Naohiro, et al.
Publicado: (2011)

Decoding the androgen receptor splice variants
por: Lu, Changxue, et al.
Publicado: (2013)

Immunohistochemical Expression of Androgen Receptors (AR) in Various Breast Cancer Subtypes
por: Ismael, Nour El Hoda S., et al.
Publicado: (2019)

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2
por: Baratchian, Mehdi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ubvvklq6s60j0tmo7ardtq95pm