Cargando…

High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer

A growing body of evidence indicates that miRNAs may be a class of genetic elements that can either drive or suppress oncogenesis. In this study we analyzed the somatic copy number variation of 14 miRNA genes frequently found to be either over- or underexpressed in lung cancer, as well as two miRNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Czubak, Karol, Lewandowska, Marzena Anna, Klonowska, Katarzyna, Roszkowski, Krzysztof, Kowalewski, Janusz, Figlerowicz, Marek, Kozlowski, Piotr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695126/ https://www.ncbi.nlm.nih.gov/pubmed/26156018

Ejemplares similares

The Use of a Two-Tiered Testing Strategy for the Simultaneous Detection of Small EGFR Mutations and EGFR Amplification in Lung Cancer
por: Lewandowska, Marzena Anna, et al.
Publicado: (2015)

Oncogenomic portals for the visualization and analysis of genome-wide cancer data
por: Klonowska, Katarzyna, et al.
Publicado: (2015)

Methylation of DROSHA and DICER as a Biomarker for the Detection of Lung Cancer
por: Szczyrek, Michał, et al.
Publicado: (2021)

Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer
por: Zhang, Xiaoxiao, et al.
Publicado: (2022)

Predicting Drosha and Dicer Cleavage Sites with DeepMirCut
por: Bell, Jimmy, et al.
Publicado: (2022)

DROSHA but not DICER is required for human haematopoietic stem cell function
por: Gu, Karen, et al.
Publicado: (2022)

Copy number polymorphism in plant genomes
por: Żmieńko, Agnieszka, et al.
Publicado: (2013)

Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer
por: Torres, Anna, et al.
Publicado: (2011)

The terminal loop region controls microRNA processing by Drosha and Dicer
por: Zhang, Xiaoxiao, et al.
Publicado: (2010)

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer
por: Johanson, Timothy M., et al.
Publicado: (2013)

The effects of DICER1 and DROSHA polymorphisms on susceptibility to recurrent spontaneous abortion
por: Ghasemi, Marzieh, et al.
Publicado: (2019)

Impact of DICER1 and DROSHA on the Angiogenic Capacity of Human Endothelial Cells
por: Braun, Heike, et al.
Publicado: (2021)

Site-specific DICER and DROSHA RNA products control the DNA damage response
por: Francia, Sofia, et al.
Publicado: (2012)

Dicer Is Down-regulated and Correlated with Drosha in Idiopathic Sudden Sensorineural Hearing Loss
por: Kim, Shin, et al.
Publicado: (2015)

Sequence Features of Drosha and Dicer Cleavage Sites Affect the Complexity of IsomiRs
por: Starega-Roslan, Julia, et al.
Publicado: (2015)

Dynamical comparison between Drosha and Dicer reveals functional motion similarities and dissimilarities
por: Aharoni, Rotem, et al.
Publicado: (2019)

Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival
por: Lønvik, Kenneth, et al.
Publicado: (2014)

The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer
por: Avery-Kiejda, Kelly A, et al.
Publicado: (2014)

Copy number variation of genes involved in the hepatitis C virus-human interactome
por: Budzko, Lucyna, et al.
Publicado: (2016)

MTTE: an innovative strategy for the evaluation of targeted/exome enrichment efficiency
por: Klonowska, Katarzyna, et al.
Publicado: (2016)

MLPA-Based Analysis of Copy Number Variation in Plant Populations
por: Samelak-Czajka, Anna, et al.
Publicado: (2017)

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors
por: Francia, Sofia, et al.
Publicado: (2016)

The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities
por: Kurzynska-Kokorniak, Anna, et al.
Publicado: (2015)

The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population
por: Klonowska, Katarzyna, et al.
Publicado: (2017)

An Overview of Circular RNAs and Their Implications in Myotonic Dystrophy
por: Czubak, Karol, et al.
Publicado: (2019)

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours
por: Rakheja, Dinesh, et al.
Publicado: (2014)

Determining Frequent Patterns of Copy Number Alterations in Cancer
por: Rapaport, Franck, et al.
Publicado: (2010)

Evaluating the Effect of 3′-UTR Variants in DICER1 and DROSHA on Their Tissue-Specific Expression by miRNA Target Prediction
por: Bug, Dmitrii S., et al.
Publicado: (2021)

Application of PCR methods to evaluate EGFR, KRAS and BRAF mutations in a small number of tumor cells in cytological material from lung cancer patients
por: LEWANDOWSKA, MARZENA ANNA, et al.
Publicado: (2013)

Publisher Correction: Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours
por: Rakheja, Dinesh, et al.
Publicado: (2017)

Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN
por: Borge, Kaja S., et al.
Publicado: (2015)

3’-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population
por: Cho, Sung Hwan, et al.
Publicado: (2015)

Detection of somatic mutations in ctDNA derived from adenocarcinoma patients – EGFR tyrosine kinase inhibitor monitoring preliminary study
por: Lewandowska, Marzena Anna, et al.
Publicado: (2019)

Expression levels of the microRNA maturing microprocessor complex components; Drosha, Dicer, and DGCR8 in PBMCs from ankylosing spondylitis patients
por: Tabrizi, Zeinab, et al.
Publicado: (2017)

Differential gene methylation patterns in cancerous and non-cancerous cells
por: Kamińska, Katarzyna, et al.
Publicado: (2019)

RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity
por: Koralewska, Natalia, et al.
Publicado: (2021)

Analysis of large mutations in BARD1 in patients with breast and/or ovarian cancer: the Polish population as an example
por: Klonowska, Katarzyna, et al.
Publicado: (2015)

Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end‐stage renal disease
por: Fawzy, Manal S., et al.
Publicado: (2020)

Revealing a new activity of the human Dicer DUF283 domain in vitro
por: Kurzynska-Kokorniak, Anna, et al.
Publicado: (2016)

The RNA–RNA base pairing potential of human Dicer and Ago2 proteins
por: Pokornowska, Maria, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jon2b1913u74jjbjmiihoi66jc