Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

Cancer cells exhibit altered metabolism including aerobic glycolysis that channels several glycolytic intermediates into de novo purine biosynthetic pathway. We discovered increased expression of phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole carboxylase, phosphoribosylamino...

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Detalles Bibliográficos
Autores principales: Goswami, Moloy T., Chen, Guoan, Chakravarthi, Balabhadrapatruni V.S.K., Pathi, Satya S., Anand, Sharath K., Carskadon, Shannon L., Giordano, Thomas J., Chinnaiyan, Arul M., Thomas, Dafydd G., Palanisamy, Nallasivam, Beer, David G., Varambally, Sooryanarayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695129/
https://www.ncbi.nlm.nih.gov/pubmed/26140362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695129/
https://www.ncbi.nlm.nih.gov/pubmed/26140362

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