A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2

Veratridine (VTD), an alkaloid derived from the Liliaceae plant shows anti-tumor effects; however, its molecular targets have not been thoroughly studied. Using a high-throughput drug screen, we found that VTD enhances transactivation of UBXN2A, resulting in upregulation of UBXN2A in the cytoplasm,...

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Detalles Bibliográficos
Autores principales: Abdullah, Ammara, Sane, Sanam, Branick, Kate A., Freeling, Jessica L., Wang, Hongmin, Zhang, Dong, Rezvani, Khosrow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695137/
https://www.ncbi.nlm.nih.gov/pubmed/26188124

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