E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines

In SiHa and CaSki cells, E6 and E7-targeting shRNA specifically and effectively knocked down human papillomavirus (HPV) 16 E6 and E7 at the transcriptional level, reduced the E6 and E7 mRNA levels by more than 80% compared with control cells that expressed a scrambled-sequence shRNA. E6 and E7 repre...

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Detalles Bibliográficos
Autores principales: Li, Liming, Xu, Cui, Long, Jia, Shen, Danbei, Zhou, Wuqing, Zhou, Qiyan, Yang, Jia, Jiang, Mingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695162/
https://www.ncbi.nlm.nih.gov/pubmed/26329329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695162/
https://www.ncbi.nlm.nih.gov/pubmed/26329329

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