Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas

Tumor initiating cells (TICs) possessing cancer stemness were shown to be enriched after therapy, resulting in the relapse and metastasis of head and neck squamous cell carcinomas (HNC). An effective therapeutic approach suppressing the HNC-TICs would be a potential method to improve the treatments...

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Detalles Bibliográficos
Autores principales: Chang, Yu-Chao, Jan, Chia-Ing, Peng, Chih-Yu, Lai, Yu-Chi, Hu, Fang-Wei, Yu, Cheng-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695166/
https://www.ncbi.nlm.nih.gov/pubmed/26090866

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