Epi-reevesioside F inhibits Na(+)/K(+)-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

Epi-reevesioside F, a new cardiac glycoside isolated from the root of Reevesia formosana, displayed potent activity against glioblastoma cells. Epi-reevesioside F was more potent than ouabain with IC(50) values of 27.3±1.7 vs. 48.7±1.8 nM (P < 0.001) and 45.0±3.4 vs. 81.3±4.3 nM (P < 0.001) in...

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Detalles Bibliográficos
Autores principales: Hsu, Jui-Ling, Liu, Fan-Lun, Hsu, Lih-Ching, Chang, Hsun-Shuo, Leu, Wohn-Jenn, Yu, Chia-Chun, Chang, Wei-Ling, Chen, Ih-Sheng, Kung, Fan-Lu, Guh, Jih-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695168/
https://www.ncbi.nlm.nih.gov/pubmed/26125228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695168/
https://www.ncbi.nlm.nih.gov/pubmed/26125228

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