Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread

Cancer associated fibroblasts (CAFs) are key determinants of cancer progression. In prostate carcinoma (PCa), CAFs induce epithelial-mesenchymal transition (EMT) and metabolic reprogramming of PCa cells towards oxidative phosphorylation (OXPHOS), promoting tumor growth and metastatic dissemination....

Descripción completa

Detalles Bibliográficos
Autores principales: Giannoni, Elisa, Taddei, Maria Letizia, Morandi, Andrea, Comito, Giuseppina, Calvani, Maura, Bianchini, Francesca, Richichi, Barbara, Raugei, Giovanni, Wong, Nicholas, Tang, Damu, Chiarugi, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695170/
https://www.ncbi.nlm.nih.gov/pubmed/26183399

Ejemplares similares

Ejemplares similares