Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism

The Akt/mTORC1 pathway plays a central role in the activation of Warburg effect in cancer. Here, we present for the first time that halofuginone (HF) treatment inhibits colorectal cancer (CRC) growth both in vitro and in vivo through regulation of Akt/mTORC1 signaling pathway. Halofuginone treatment...

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Detalles Bibliográficos
Autores principales: Chen, Guo-Qing, Tang, Cheng-Fang, Shi, Xiao-Ke, Lin, Cheng-Yuan, Fatima, Sarwat, Pan, Xiao-Hua, Yang, Da-Jian, Zhang, Ge, Lu, Ai-Ping, Lin, Shu-Hai, Bian, Zhao-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695176/
https://www.ncbi.nlm.nih.gov/pubmed/26160839

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