Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation

Multiple myeloma (MM) is a clinically and genetically heterogeneous plasma cell (PC) malignancy. Whole-exome sequencing has identified therapeutically targetable mutations such as those in the mitogen-activated protein kinase (MAPK) pathway, which are the most prevalent MM mutations. We used deep se...

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Detalles Bibliográficos
Autores principales: Lionetti, Marta, Barbieri, Marzia, Todoerti, Katia, Agnelli, Luca, Marzorati, Simona, Fabris, Sonia, Ciceri, Gabriella, Galletti, Serena, Milesi, Giulia, Manzoni, Martina, Mazzoni, Mara, Greco, Angela, Tonon, Giovanni, Musto, Pellegrino, Baldini, Luca, Neri, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695180/
https://www.ncbi.nlm.nih.gov/pubmed/26090869

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