Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

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Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine,...

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Detalles Bibliográficos
Autores principales: Hettmer, Simone, Schinzel, Anna C, Tchessalova, Daria, Schneider, Michaela, Parker, Christina L, Bronson, Roderick T, Richards, Nigel GJ, Hahn, William C, Wagers, Amy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695385/
https://www.ncbi.nlm.nih.gov/pubmed/26499495
http://dx.doi.org/10.7554/eLife.09436
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