Cargando…

Molecular dynamic simulations of Escherichia colil-asparaginase to illuminate its role in deamination of asparagine and glutamine residues

Acute lymphocytic leukemia (ALL) is an outrageous disease worldwide. l-Asparagine (l-Asn) and l-Glutamine (l-Gln) deamination play a crucial role in ALL treatment. Role of Elspar(®) (l-asparaginase from Escherichia coli) in regulation of l-Asn and l-Gln has been confirmed by the other researchers th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Erva, Rajeswara Reddy, Rajulapati, Satish Babu, Potla Durthi, Chandrasai, Bhatia, Mayuri, Pola, Madhuri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695448/ https://www.ncbi.nlm.nih.gov/pubmed/28330072 http://dx.doi.org/10.1007/s13205-015-0339-9

Ejemplares similares

Exploration of the binding modes of l-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation
por: Reddy, Erva Rajeswara, et al.
Publicado: (2016)

Low Bioavailability and High Immunogenicity of a New Brand of E. colil-Asparaginase with Active Host Contaminating Proteins
por: Zenatti, Priscila Pini, et al.
Publicado: (2018)

Synthesis and implication of novel poly(acrylic acid)/nanosorbent embedded hydrogel composite for lead ion removal
por: Bhatia, Mayuri, et al.
Publicado: (2017)

Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: A computational study
por: Peele, K. Abraham, et al.
Publicado: (2020)

The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity
por: Nguyen, Hien Anh, et al.
Publicado: (2017)

Colil: a database and search service for citation contexts in the life sciences domain
por: Fujiwara, Toyofumi, et al.
Publicado: (2015)

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma
por: Ratnikov, Boris, et al.
Publicado: (2015)

Controlling the prion propensity of glutamine/asparagine-rich proteins
por: Paul, Kacy R, et al.
Publicado: (2015)

A temporal and spatial contribution of asparaginase to asparagine catabolism during development of rice grains
por: Yabuki, Yui, et al.
Publicado: (2017)

Asparagine, a critical limiting metabolite during glutamine starvation
por: Jiang, Jie, et al.
Publicado: (2018)

STUDIES ON THE MECHANISM OF TUMOR INHIBITION BY L-ASPARAGINASE : EFFECTS OF THE ENZYME ON ASPARAGINE LEVELS IN THE BLOOD, NORMAL TISSUES, AND 6C3HED LYMPHOMAS OF MICE: DIFFERENCES IN ASPARAGINE FORMATION AND UTILIZATION IN ASPARAGINASE-SENSITIVE AND -RESISTANT LYMPHOMA CELLS
por: Broome, J. D.
Publicado: (1968)

Deamidation Reactions of Asparagine- and Glutamine-Containing Dipeptides Investigated by Ion Spectroscopy
por: Kempkes, Lisanne J. M., et al.
Publicado: (2016)

Primary cilia sense glutamine availability and respond via asparagine synthetase
por: Steidl, Maria Elena, et al.
Publicado: (2023)

Asparagine synthetase expression is associated with the sensitivity to asparaginase in extranodal natural killer/T-cell lymphoma in vivo and in vitro
por: Liu, Wen-jian, et al.
Publicado: (2018)

ALL blasts drive primary mesenchymal stromal cells to increase asparagine availability during asparaginase treatment
por: Chiu, Martina, et al.
Publicado: (2021)

P334: ULTIMATE CLARIFICATION OF THE RELATIONSHIP BETWEEN ASPARAGINE SYNTHETASE ACTIVITY AND SENSITIVITY OF LEUKEMIA TO L-ASPARAGINASE
por: Hlozkova, Katerina, et al.
Publicado: (2023)

Improvement of Soybean Agrobacterium-Mediated Transformation Efficiency by Adding Glutamine and Asparagine into the Culture Media
por: Chen, Li, et al.
Publicado: (2018)

SLC1A5 provides glutamine and asparagine necessary for bone development in mice
por: Sharma, Deepika, et al.
Publicado: (2021)

In Vitro Anti-HIV-1 Activity of Chitosan Oligomers N-Conjugated with Asparagine and Glutamine
por: Karadeniz, Fatih
Publicado: (2023)

NQ-Flipper: recognition and correction of erroneous asparagine and glutamine side-chain rotamers in protein structures
por: Weichenberger, Christian X., et al.
Publicado: (2007)

Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation
por: Pant, Anil, et al.
Publicado: (2019)

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells
por: Riemschoss, Katrin, et al.
Publicado: (2019)

Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability
por: Chiu, Martina, et al.
Publicado: (2020)

Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy
por: Kuo, Macus Tien, et al.
Publicado: (2021)

Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed‐batch process
por: Kirsch, Brian J., et al.
Publicado: (2022)

Deamination of 5-Methylcytosine Residues in Mammalian Cells
por: Gromenko, E.V., et al.
Publicado: (2009)

Deaminative chlorination of aminoheterocycles
por: Ghiazza, Clément, et al.
Publicado: (2021)

A Facile Synthesis of α-N-Ribosyl-Asparagine and α-N-Ribosyl-Glutamine Building Blocks
por: Speciale, Gaetano, et al.
Publicado: (2013)

Hypermethylation of CpG islands in the mouse asparagine synthetase gene: relationship to asparaginase sensitivity in lymphoma cells. Partial methylation in normal cells
por: Peng, H, et al.
Publicado: (2001)

Monitoring of asparagine depletion and anti-l-asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial
por: Paillassa, Jérôme, et al.
Publicado: (2018)

A clinically attainable dose of L‐asparaginase targets glutamine addiction in lymphoid cell lines
por: Sugimoto, Koichi, et al.
Publicado: (2015)

Thermal decomposition of the amino acids glycine, cysteine, aspartic acid, asparagine, glutamic acid, glutamine, arginine and histidine
por: Weiss, Ingrid M., et al.
Publicado: (2018)

A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus
por: Zhu, Ying, et al.
Publicado: (2017)

Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study
por: Rizzari, Carmelo, et al.
Publicado: (2019)

PrionW: a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores
por: Zambrano, Rafael, et al.
Publicado: (2015)

Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase()()
por: Toda, Kosuke, et al.
Publicado: (2016)

Light-Independent Nitrogen Assimilation in Plant Leaves: Nitrate Incorporation into Glutamine, Glutamate, Aspartate, and Asparagine Traced by (15)N
por: Yoneyama, Tadakatsu, et al.
Publicado: (2020)

Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein()
por: Duquerroy, Stéphane, et al.
Publicado: (2005)

Gut bacterial deamination of residual levodopa medication for Parkinson’s disease
por: van Kessel, Sebastiaan P., et al.
Publicado: (2020)

THE COMBINATION OF DEAMINIZED GELATIN WITH HYDROCHLORIC ACID
por: Hitchcock, David I.
Publicado: (1923)

Cannot write session to /tmp/vufind_sessions/sess_hl7i2lsc3linquntmnu8jms1t6