Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling

Discussions of therapeutic suppression of hedgehog (Hh) signaling almost exclusively focus on receptor antagonism; however, hedgehog’s biosynthesis represents a unique and potentially targetable aspect of this oncogenic signaling pathway. Here, we review a key biosynthetic step called cholesterolysi...

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Detalles Bibliográficos
Autores principales: Callahan, Brian P., Wang, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695875/
https://www.ncbi.nlm.nih.gov/pubmed/26473928
http://dx.doi.org/10.3390/cancers7040875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695875/
https://www.ncbi.nlm.nih.gov/pubmed/26473928
http://dx.doi.org/10.3390/cancers7040875

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