Cargando…
Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling
Discussions of therapeutic suppression of hedgehog (Hh) signaling almost exclusively focus on receptor antagonism; however, hedgehog’s biosynthesis represents a unique and potentially targetable aspect of this oncogenic signaling pathway. Here, we review a key biosynthetic step called cholesterolysi...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695875/ https://www.ncbi.nlm.nih.gov/pubmed/26473928 http://dx.doi.org/10.3390/cancers7040875 |