Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation

BACKGROUND: Fingolimod (FTY720), the first oral treatment for multiple sclerosis (MS), blocks immune cell trafficking and prevents disease relapses by downregulation of sphingosine-1-phosphate receptor. We determined the effect of FTY720 on human T cell activation and effector function. METHODS: T c...

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Detalles Bibliográficos
Autores principales: Mazzola, Maria Antonietta, Raheja, Radhika, Murugaiyan, Gopal, Rajabi, Hasan, Kumar, Deepak, Pertel, Thomas, Regev, Keren, Griffin, Russell, Aly, Lilian, Kivisakk, Pia, Nejad, Parham, Patel, Bonny, Gwanyalla, Nguendab, Hei, Hillary, Glanz, Bonnie, Chitnis, Tanuja, Weiner, Howard L., Gandhi, Roopali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696082/
https://www.ncbi.nlm.nih.gov/pubmed/26714756
http://dx.doi.org/10.1186/s12974-015-0460-z

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