A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1

BACKGROUND: Aberrant activation of the Wnt/β-catenin pathway is a major and frequent event in liver cancer, but inhibition of oncogenic β-catenin signaling has proven challenging. The identification of genes that are synthetically lethal in β-catenin-activated cancer cells would provide new targets...

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Detalles Bibliográficos
Autores principales: Canal, Frédéric, Anthony, Elodie, Lescure, Aurianne, Del Nery, Elaine, Camonis, Jacques, Perez, Franck, Ragazzon, Bruno, Perret, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696130/
https://www.ncbi.nlm.nih.gov/pubmed/26715116
http://dx.doi.org/10.1186/s12885-015-2037-8

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