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Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease

BACKGROUND: Cardiovascular damages poses risks to children with Kawasaki disease (KD). Although hypertriglyceridemia and hypercholesteremia are risk factors of cardiovascular damages, studies on the blood lipid metabolism in KD are still limited. This study aims to analyze the blood lipids and coagu...

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Autores principales: Chen, Xi, Zhao, Zhen-Wen, Li, Lin, Chen, Xue-Jun, Xu, Hui, Lou, Jin-Tu, Li, Lin-Jie, Du, Li-Zhong, Xie, Chun-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696131/
https://www.ncbi.nlm.nih.gov/pubmed/26714775
http://dx.doi.org/10.1186/s12944-015-0167-2
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author Chen, Xi
Zhao, Zhen-Wen
Li, Lin
Chen, Xue-Jun
Xu, Hui
Lou, Jin-Tu
Li, Lin-Jie
Du, Li-Zhong
Xie, Chun-Hong
author_facet Chen, Xi
Zhao, Zhen-Wen
Li, Lin
Chen, Xue-Jun
Xu, Hui
Lou, Jin-Tu
Li, Lin-Jie
Du, Li-Zhong
Xie, Chun-Hong
author_sort Chen, Xi
collection PubMed
description BACKGROUND: Cardiovascular damages poses risks to children with Kawasaki disease (KD). Although hypertriglyceridemia and hypercholesteremia are risk factors of cardiovascular damages, studies on the blood lipid metabolism in KD are still limited. This study aims to analyze the blood lipids and coagulation in KD. METHODS: Triglyceride (TG) and cholesterol levels in the plasma and serum from 20 children with KD were examined in comparison with 10 healthy children (HC) as well as 10 children with high fever from identified bacterial infections (BT). Using electrospray ionization mass spectrometry, we profiled the lipid species. Blood coagulation was analyzed. Statistics was analyzed by one-way ANOVA using SigmaStat. RESULTS: We found that in KD, plasma TG level was significantly increased, but not serum TG. A total of 19 molecular species of TG were identified, and they were all increased in KD and BT patients, and more pronounced in KD. On the other hand, major molecular species of plasma phosphotidylcholine and lyso-phosphotidylcholine were decreased in KD and BT. Pronounced hypercoagulation was found in KD blood. CONCLUSION: Our data indicate hyperlipidemia in KD, especially for TG, which contributes to the hypercoagulation and the potential risk of cardiovascular damages. Evaluation of blood lipid levels in severe KD patients could provide valuable information for treatment and prognosis, thus would be worthy of consideration. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12944-015-0167-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-46961312015-12-31 Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease Chen, Xi Zhao, Zhen-Wen Li, Lin Chen, Xue-Jun Xu, Hui Lou, Jin-Tu Li, Lin-Jie Du, Li-Zhong Xie, Chun-Hong Lipids Health Dis Research BACKGROUND: Cardiovascular damages poses risks to children with Kawasaki disease (KD). Although hypertriglyceridemia and hypercholesteremia are risk factors of cardiovascular damages, studies on the blood lipid metabolism in KD are still limited. This study aims to analyze the blood lipids and coagulation in KD. METHODS: Triglyceride (TG) and cholesterol levels in the plasma and serum from 20 children with KD were examined in comparison with 10 healthy children (HC) as well as 10 children with high fever from identified bacterial infections (BT). Using electrospray ionization mass spectrometry, we profiled the lipid species. Blood coagulation was analyzed. Statistics was analyzed by one-way ANOVA using SigmaStat. RESULTS: We found that in KD, plasma TG level was significantly increased, but not serum TG. A total of 19 molecular species of TG were identified, and they were all increased in KD and BT patients, and more pronounced in KD. On the other hand, major molecular species of plasma phosphotidylcholine and lyso-phosphotidylcholine were decreased in KD and BT. Pronounced hypercoagulation was found in KD blood. CONCLUSION: Our data indicate hyperlipidemia in KD, especially for TG, which contributes to the hypercoagulation and the potential risk of cardiovascular damages. Evaluation of blood lipid levels in severe KD patients could provide valuable information for treatment and prognosis, thus would be worthy of consideration. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12944-015-0167-2) contains supplementary material, which is available to authorized users. BioMed Central 2015-12-30 /pmc/articles/PMC4696131/ /pubmed/26714775 http://dx.doi.org/10.1186/s12944-015-0167-2 Text en © Chen et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chen, Xi
Zhao, Zhen-Wen
Li, Lin
Chen, Xue-Jun
Xu, Hui
Lou, Jin-Tu
Li, Lin-Jie
Du, Li-Zhong
Xie, Chun-Hong
Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease
title Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease
title_full Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease
title_fullStr Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease
title_full_unstemmed Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease
title_short Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease
title_sort hypercoagulation and elevation of blood triglycerides are characteristics of kawasaki disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696131/
https://www.ncbi.nlm.nih.gov/pubmed/26714775
http://dx.doi.org/10.1186/s12944-015-0167-2
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