FRMD3 gene: its role in diabetic kidney disease. A narrative review

Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide associatio...

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Autores principales: Buffon, Marjoriê Piuco, Sortica, Denise Alves, Gerchman, Fernando, Crispim, Daisy, Canani, Luís Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696171/
https://www.ncbi.nlm.nih.gov/pubmed/26719775
http://dx.doi.org/10.1186/s13098-015-0114-4
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author Buffon, Marjoriê Piuco
Sortica, Denise Alves
Gerchman, Fernando
Crispim, Daisy
Canani, Luís Henrique
author_facet Buffon, Marjoriê Piuco
Sortica, Denise Alves
Gerchman, Fernando
Crispim, Daisy
Canani, Luís Henrique
author_sort Buffon, Marjoriê Piuco
collection PubMed
description Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.
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spelling pubmed-46961712015-12-31 FRMD3 gene: its role in diabetic kidney disease. A narrative review Buffon, Marjoriê Piuco Sortica, Denise Alves Gerchman, Fernando Crispim, Daisy Canani, Luís Henrique Diabetol Metab Syndr Review Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD. BioMed Central 2015-12-30 /pmc/articles/PMC4696171/ /pubmed/26719775 http://dx.doi.org/10.1186/s13098-015-0114-4 Text en © Buffon et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Buffon, Marjoriê Piuco
Sortica, Denise Alves
Gerchman, Fernando
Crispim, Daisy
Canani, Luís Henrique
FRMD3 gene: its role in diabetic kidney disease. A narrative review
title FRMD3 gene: its role in diabetic kidney disease. A narrative review
title_full FRMD3 gene: its role in diabetic kidney disease. A narrative review
title_fullStr FRMD3 gene: its role in diabetic kidney disease. A narrative review
title_full_unstemmed FRMD3 gene: its role in diabetic kidney disease. A narrative review
title_short FRMD3 gene: its role in diabetic kidney disease. A narrative review
title_sort frmd3 gene: its role in diabetic kidney disease. a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696171/
https://www.ncbi.nlm.nih.gov/pubmed/26719775
http://dx.doi.org/10.1186/s13098-015-0114-4
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