Antagonist of the neurokinin-1 receptor curbs neuroinflammation in ex vivo and in vitro models of Lyme neuroborreliosis

BACKGROUND: Lyme neuroborreliosis (LNB) can affect both the peripheral (PNS) and the central nervous systems (CNS); it is caused by the spirochete Borrelia burgdorferi. The neuropeptide substance P (SP) is an important mediator of both neuroinflammation and blood-brain barrier dysfunction, through i...

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Detalles Bibliográficos
Autores principales: Martinez, Alejandra N., Ramesh, Geeta, Jacobs, Mary B., Philipp, Mario T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696197/
https://www.ncbi.nlm.nih.gov/pubmed/26714480
http://dx.doi.org/10.1186/s12974-015-0453-y

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