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Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage
BACKGROUND: The mean platelet volume (MPV) is the most commonly used measure of platelet size and is a potential marker of platelet reactivity. In this study, we aimed to explore the relationship between hepatic histopathology in viral hepatitis and MPV levels, which are associated with platelet cou...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696372/ https://www.ncbi.nlm.nih.gov/pubmed/26759574 http://dx.doi.org/10.4103/1735-1995.170609 |
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author | Eminler, Ahmet Tarik Uslan, Mustafa Ihsan Ayyildiz, Talat Irak, Kader Kiyici, Murat Gurel, Selim Dolar, Enver Gulten, Macit Nak, Selim Giray |
author_facet | Eminler, Ahmet Tarik Uslan, Mustafa Ihsan Ayyildiz, Talat Irak, Kader Kiyici, Murat Gurel, Selim Dolar, Enver Gulten, Macit Nak, Selim Giray |
author_sort | Eminler, Ahmet Tarik |
collection | PubMed |
description | BACKGROUND: The mean platelet volume (MPV) is the most commonly used measure of platelet size and is a potential marker of platelet reactivity. In this study, we aimed to explore the relationship between hepatic histopathology in viral hepatitis and MPV levels, which are associated with platelet count and activity. MATERIALS AND METHODS: We performed a retrospective case-control study of baseline histological and clinical parameters in chronic hepatitis B and C patients in our tertiary reference center between January 2005 and January 2011. Two hundred and five chronic hepatitis B patients and 133 chronic hepatitis C patients who underwent liver biopsy were included in the study. The patients were divided into two groups: Chronic hepatitis B and chronic hepatitis C and were additionally divided into groups of two according to histological activity index (HAI) and fibrosis scores obtained by liver biopsy results (according to the Ishak scoring system). The clinical characteristics of chronic viral hepatitis patients, including demographics, laboratory (especially MPV), and liver biopsy findings, were reviewed. RESULTS: One hundred and forty-three patients were male (69.1%), and the mean age was 41.9 ± 12.75 with an age range of 18-71 years in hepatitis B patients. In the classification made according to HAI, 181 patients were in the low activity group (88.3%) and 24 in the high activity group (11.7%). In the evaluation made according to fibrosis score, 169 patients were found to have early fibrosis (82.4%) and 36 were found to have advanced fibrosis (17.6%). In patients with hepatitis B, there was no statistically significant difference in terms of their MPV values between the two groups, separated according to their degree of activity and fibrosis. Sixty-three patients were male (47.3%), and the mean age was 50.03 ± 12.75 with an age range of 19-75 years. In the classification made according to HAI, 109 patients were in low activity group (81.9%) and 24 in high activity group (18.1%). In the evaluation made according to fibrosis score, 101 patients were found to have early fibrosis (75.9%) and 32 have advanced fibrosis (24.1%). There was a statistically significant difference between the activity and fibrosis groups of the hepatitis C patients (P = 0.04 and P = 0.02, respectively). CONCLUSION: MPV values are more reliable in hepatitis C patients than hepatitis B for predicting the advanced damage in liver histology. This finding might be useful for the detection of early fibrosis and also starting early treatment, which is important in hepatitis C. |
format | Online Article Text |
id | pubmed-4696372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46963722016-01-12 Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage Eminler, Ahmet Tarik Uslan, Mustafa Ihsan Ayyildiz, Talat Irak, Kader Kiyici, Murat Gurel, Selim Dolar, Enver Gulten, Macit Nak, Selim Giray J Res Med Sci Original Article BACKGROUND: The mean platelet volume (MPV) is the most commonly used measure of platelet size and is a potential marker of platelet reactivity. In this study, we aimed to explore the relationship between hepatic histopathology in viral hepatitis and MPV levels, which are associated with platelet count and activity. MATERIALS AND METHODS: We performed a retrospective case-control study of baseline histological and clinical parameters in chronic hepatitis B and C patients in our tertiary reference center between January 2005 and January 2011. Two hundred and five chronic hepatitis B patients and 133 chronic hepatitis C patients who underwent liver biopsy were included in the study. The patients were divided into two groups: Chronic hepatitis B and chronic hepatitis C and were additionally divided into groups of two according to histological activity index (HAI) and fibrosis scores obtained by liver biopsy results (according to the Ishak scoring system). The clinical characteristics of chronic viral hepatitis patients, including demographics, laboratory (especially MPV), and liver biopsy findings, were reviewed. RESULTS: One hundred and forty-three patients were male (69.1%), and the mean age was 41.9 ± 12.75 with an age range of 18-71 years in hepatitis B patients. In the classification made according to HAI, 181 patients were in the low activity group (88.3%) and 24 in the high activity group (11.7%). In the evaluation made according to fibrosis score, 169 patients were found to have early fibrosis (82.4%) and 36 were found to have advanced fibrosis (17.6%). In patients with hepatitis B, there was no statistically significant difference in terms of their MPV values between the two groups, separated according to their degree of activity and fibrosis. Sixty-three patients were male (47.3%), and the mean age was 50.03 ± 12.75 with an age range of 19-75 years. In the classification made according to HAI, 109 patients were in low activity group (81.9%) and 24 in high activity group (18.1%). In the evaluation made according to fibrosis score, 101 patients were found to have early fibrosis (75.9%) and 32 have advanced fibrosis (24.1%). There was a statistically significant difference between the activity and fibrosis groups of the hepatitis C patients (P = 0.04 and P = 0.02, respectively). CONCLUSION: MPV values are more reliable in hepatitis C patients than hepatitis B for predicting the advanced damage in liver histology. This finding might be useful for the detection of early fibrosis and also starting early treatment, which is important in hepatitis C. Medknow Publications & Media Pvt Ltd 2015-09 /pmc/articles/PMC4696372/ /pubmed/26759574 http://dx.doi.org/10.4103/1735-1995.170609 Text en Copyright: © 2015 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Eminler, Ahmet Tarik Uslan, Mustafa Ihsan Ayyildiz, Talat Irak, Kader Kiyici, Murat Gurel, Selim Dolar, Enver Gulten, Macit Nak, Selim Giray Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage |
title | Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage |
title_full | Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage |
title_fullStr | Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage |
title_full_unstemmed | Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage |
title_short | Mean platelet volume is an important predictor of hepatitis C but not hepatitis B liver damage |
title_sort | mean platelet volume is an important predictor of hepatitis c but not hepatitis b liver damage |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696372/ https://www.ncbi.nlm.nih.gov/pubmed/26759574 http://dx.doi.org/10.4103/1735-1995.170609 |
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