Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo

The depletion of stem cell pools and the accumulation of senescent cells in animal tissues are linked to aging. Planarians are invertebrate flatworms and are unusual in that their stem cells, called neoblasts, are constantly replacing old and dying cells. By eliminating neoblasts in worms via irradi...

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Autores principales: Perrigue, Patrick M., Najbauer, Joseph, Jozwiak, Agnieszka A., Barciszewski, Jan, Aboody, Karen S., Barish, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2015
Materias:
Animal Model Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696462/
https://www.ncbi.nlm.nih.gov/pubmed/26654402
http://dx.doi.org/10.3402/pba.v5.30052
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author Perrigue, Patrick M.
Najbauer, Joseph
Jozwiak, Agnieszka A.
Barciszewski, Jan
Aboody, Karen S.
Barish, Michael E.
author_facet Perrigue, Patrick M.
Najbauer, Joseph
Jozwiak, Agnieszka A.
Barciszewski, Jan
Aboody, Karen S.
Barish, Michael E.
author_sort Perrigue, Patrick M.
collection PubMed
description The depletion of stem cell pools and the accumulation of senescent cells in animal tissues are linked to aging. Planarians are invertebrate flatworms and are unusual in that their stem cells, called neoblasts, are constantly replacing old and dying cells. By eliminating neoblasts in worms via irradiation, the biological principles of aging are exposed in the absence of wound healing and regeneration, making planaria a powerful tool for aging research.
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spelling pubmed-46964622016-01-15 Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo Perrigue, Patrick M. Najbauer, Joseph Jozwiak, Agnieszka A. Barciszewski, Jan Aboody, Karen S. Barish, Michael E. Pathobiol Aging Age Relat Dis Animal Model Brief The depletion of stem cell pools and the accumulation of senescent cells in animal tissues are linked to aging. Planarians are invertebrate flatworms and are unusual in that their stem cells, called neoblasts, are constantly replacing old and dying cells. By eliminating neoblasts in worms via irradiation, the biological principles of aging are exposed in the absence of wound healing and regeneration, making planaria a powerful tool for aging research. Co-Action Publishing 2015-12-10 /pmc/articles/PMC4696462/ /pubmed/26654402 http://dx.doi.org/10.3402/pba.v5.30052 Text en © 2015 Patrick M. Perrigue et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal Model Brief
Perrigue, Patrick M.
Najbauer, Joseph
Jozwiak, Agnieszka A.
Barciszewski, Jan
Aboody, Karen S.
Barish, Michael E.
Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
title Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
title_full Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
title_fullStr Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
title_full_unstemmed Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
title_short Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
title_sort planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
topic Animal Model Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696462/
https://www.ncbi.nlm.nih.gov/pubmed/26654402
http://dx.doi.org/10.3402/pba.v5.30052
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