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Intrinsic brain indices of verbal working memory capacity in children and adolescents
Working memory (WM) is central to the acquisition of knowledge and skills throughout childhood and adolescence. While numerous behavioral and task-based functional magnetic resonance imaging (fMRI) studies have examined WM development, few have used resting-state fMRI (R-fMRI). Here, we present a sy...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696540/ https://www.ncbi.nlm.nih.gov/pubmed/26299314 http://dx.doi.org/10.1016/j.dcn.2015.07.007 |
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author | Yang, Zhen Jutagir, Devika R. Koyama, Maki S. Craddock, R. Cameron Yan, Chao-Gan Shehzad, Zarrar Castellanos, F. Xavier Di Martino, Adriana Milham, Michael P. |
author_facet | Yang, Zhen Jutagir, Devika R. Koyama, Maki S. Craddock, R. Cameron Yan, Chao-Gan Shehzad, Zarrar Castellanos, F. Xavier Di Martino, Adriana Milham, Michael P. |
author_sort | Yang, Zhen |
collection | PubMed |
description | Working memory (WM) is central to the acquisition of knowledge and skills throughout childhood and adolescence. While numerous behavioral and task-based functional magnetic resonance imaging (fMRI) studies have examined WM development, few have used resting-state fMRI (R-fMRI). Here, we present a systematic R-fMRI examination of age-related differences in the neural indices of verbal WM performance in a cross-sectional pediatric sample (ages: 7–17; n = 68), using data-driven approaches. Verbal WM capacity was measured with the digit span task, a commonly used educational and clinical assessment. We found distinct neural indices of digit span forward (DSF) and backward (DSB) performance, reflecting their unique neuropsychological demands. Regardless of age, DSB performance was related to intrinsic properties of brain areas previously implicated in attention and cognitive control, while DSF performance was related to areas less commonly implicated in verbal WM storage (precuneus, lateral visual areas). From a developmental perspective, DSF exhibited more robust age-related differences in brain–behavior relationships than DSB, and implicated a broader range of networks (ventral attention, default, somatomotor, limbic networks) – including a number of regions not commonly associated with verbal WM (angular gyrus, subcallosum). These results highlight the importance of examining the neurodevelopment of verbal WM and of considering regions beyond the “usual suspects”. |
format | Online Article Text |
id | pubmed-4696540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-46965402016-10-01 Intrinsic brain indices of verbal working memory capacity in children and adolescents Yang, Zhen Jutagir, Devika R. Koyama, Maki S. Craddock, R. Cameron Yan, Chao-Gan Shehzad, Zarrar Castellanos, F. Xavier Di Martino, Adriana Milham, Michael P. Dev Cogn Neurosci Imaging the Developing Brain: the 1st International Conference of Human Brain Development Working memory (WM) is central to the acquisition of knowledge and skills throughout childhood and adolescence. While numerous behavioral and task-based functional magnetic resonance imaging (fMRI) studies have examined WM development, few have used resting-state fMRI (R-fMRI). Here, we present a systematic R-fMRI examination of age-related differences in the neural indices of verbal WM performance in a cross-sectional pediatric sample (ages: 7–17; n = 68), using data-driven approaches. Verbal WM capacity was measured with the digit span task, a commonly used educational and clinical assessment. We found distinct neural indices of digit span forward (DSF) and backward (DSB) performance, reflecting their unique neuropsychological demands. Regardless of age, DSB performance was related to intrinsic properties of brain areas previously implicated in attention and cognitive control, while DSF performance was related to areas less commonly implicated in verbal WM storage (precuneus, lateral visual areas). From a developmental perspective, DSF exhibited more robust age-related differences in brain–behavior relationships than DSB, and implicated a broader range of networks (ventral attention, default, somatomotor, limbic networks) – including a number of regions not commonly associated with verbal WM (angular gyrus, subcallosum). These results highlight the importance of examining the neurodevelopment of verbal WM and of considering regions beyond the “usual suspects”. Elsevier 2015-08-04 /pmc/articles/PMC4696540/ /pubmed/26299314 http://dx.doi.org/10.1016/j.dcn.2015.07.007 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Imaging the Developing Brain: the 1st International Conference of Human Brain Development Yang, Zhen Jutagir, Devika R. Koyama, Maki S. Craddock, R. Cameron Yan, Chao-Gan Shehzad, Zarrar Castellanos, F. Xavier Di Martino, Adriana Milham, Michael P. Intrinsic brain indices of verbal working memory capacity in children and adolescents |
title | Intrinsic brain indices of verbal working memory capacity in children and adolescents |
title_full | Intrinsic brain indices of verbal working memory capacity in children and adolescents |
title_fullStr | Intrinsic brain indices of verbal working memory capacity in children and adolescents |
title_full_unstemmed | Intrinsic brain indices of verbal working memory capacity in children and adolescents |
title_short | Intrinsic brain indices of verbal working memory capacity in children and adolescents |
title_sort | intrinsic brain indices of verbal working memory capacity in children and adolescents |
topic | Imaging the Developing Brain: the 1st International Conference of Human Brain Development |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696540/ https://www.ncbi.nlm.nih.gov/pubmed/26299314 http://dx.doi.org/10.1016/j.dcn.2015.07.007 |
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