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Waterborne Elizabethkingia meningoseptica in Adult Critical Care
Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696684/ https://www.ncbi.nlm.nih.gov/pubmed/26690562 http://dx.doi.org/10.3201/eid2201.150139 |
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author | Moore, Luke S.P. Owens, Daniel S. Jepson, Annette Turton, Jane F. Ashworth, Simon Donaldson, Hugo Holmes, Alison H. |
author_facet | Moore, Luke S.P. Owens, Daniel S. Jepson, Annette Turton, Jane F. Ashworth, Simon Donaldson, Hugo Holmes, Alison H. |
author_sort | Moore, Luke S.P. |
collection | PubMed |
description | Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome >2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source–associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen. |
format | Online Article Text |
id | pubmed-4696684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-46966842016-01-05 Waterborne Elizabethkingia meningoseptica in Adult Critical Care Moore, Luke S.P. Owens, Daniel S. Jepson, Annette Turton, Jane F. Ashworth, Simon Donaldson, Hugo Holmes, Alison H. Emerg Infect Dis Research Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome >2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source–associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen. Centers for Disease Control and Prevention 2016-01 /pmc/articles/PMC4696684/ /pubmed/26690562 http://dx.doi.org/10.3201/eid2201.150139 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Moore, Luke S.P. Owens, Daniel S. Jepson, Annette Turton, Jane F. Ashworth, Simon Donaldson, Hugo Holmes, Alison H. Waterborne Elizabethkingia meningoseptica in Adult Critical Care |
title | Waterborne Elizabethkingia meningoseptica in Adult Critical Care |
title_full | Waterborne Elizabethkingia meningoseptica in Adult Critical Care |
title_fullStr | Waterborne Elizabethkingia meningoseptica in Adult Critical Care |
title_full_unstemmed | Waterborne Elizabethkingia meningoseptica in Adult Critical Care |
title_short | Waterborne Elizabethkingia meningoseptica in Adult Critical Care |
title_sort | waterborne elizabethkingia meningoseptica in adult critical care |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696684/ https://www.ncbi.nlm.nih.gov/pubmed/26690562 http://dx.doi.org/10.3201/eid2201.150139 |
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