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Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissue...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696717/ https://www.ncbi.nlm.nih.gov/pubmed/26691850 http://dx.doi.org/10.3201/eid2201.151384 |
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author | Siebrasse, Erica A. Nguyen, Nang L. Willby, Melisa J. Erdman, Dean D. Menegus, Marilyn A. Wang, David |
author_facet | Siebrasse, Erica A. Nguyen, Nang L. Willby, Melisa J. Erdman, Dean D. Menegus, Marilyn A. Wang, David |
author_sort | Siebrasse, Erica A. |
collection | PubMed |
description | WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient. |
format | Online Article Text |
id | pubmed-4696717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-46967172016-01-05 Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient Siebrasse, Erica A. Nguyen, Nang L. Willby, Melisa J. Erdman, Dean D. Menegus, Marilyn A. Wang, David Emerg Infect Dis Research WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient. Centers for Disease Control and Prevention 2016-01 /pmc/articles/PMC4696717/ /pubmed/26691850 http://dx.doi.org/10.3201/eid2201.151384 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Siebrasse, Erica A. Nguyen, Nang L. Willby, Melisa J. Erdman, Dean D. Menegus, Marilyn A. Wang, David Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient |
title | Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient |
title_full | Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient |
title_fullStr | Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient |
title_full_unstemmed | Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient |
title_short | Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient |
title_sort | multiorgan wu polyomavirus infection in bone marrow transplant recipient |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696717/ https://www.ncbi.nlm.nih.gov/pubmed/26691850 http://dx.doi.org/10.3201/eid2201.151384 |
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