Cargando…

Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient

WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissue...

Descripción completa

Detalles Bibliográficos
Autores principales: Siebrasse, Erica A., Nguyen, Nang L., Willby, Melisa J., Erdman, Dean D., Menegus, Marilyn A., Wang, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696717/
https://www.ncbi.nlm.nih.gov/pubmed/26691850
http://dx.doi.org/10.3201/eid2201.151384
_version_ 1782407821641383936
author Siebrasse, Erica A.
Nguyen, Nang L.
Willby, Melisa J.
Erdman, Dean D.
Menegus, Marilyn A.
Wang, David
author_facet Siebrasse, Erica A.
Nguyen, Nang L.
Willby, Melisa J.
Erdman, Dean D.
Menegus, Marilyn A.
Wang, David
author_sort Siebrasse, Erica A.
collection PubMed
description WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.
format Online
Article
Text
id pubmed-4696717
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-46967172016-01-05 Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient Siebrasse, Erica A. Nguyen, Nang L. Willby, Melisa J. Erdman, Dean D. Menegus, Marilyn A. Wang, David Emerg Infect Dis Research WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient. Centers for Disease Control and Prevention 2016-01 /pmc/articles/PMC4696717/ /pubmed/26691850 http://dx.doi.org/10.3201/eid2201.151384 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Siebrasse, Erica A.
Nguyen, Nang L.
Willby, Melisa J.
Erdman, Dean D.
Menegus, Marilyn A.
Wang, David
Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
title Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
title_full Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
title_fullStr Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
title_full_unstemmed Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
title_short Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient
title_sort multiorgan wu polyomavirus infection in bone marrow transplant recipient
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696717/
https://www.ncbi.nlm.nih.gov/pubmed/26691850
http://dx.doi.org/10.3201/eid2201.151384
work_keys_str_mv AT siebrasseericaa multiorganwupolyomavirusinfectioninbonemarrowtransplantrecipient
AT nguyennangl multiorganwupolyomavirusinfectioninbonemarrowtransplantrecipient
AT willbymelisaj multiorganwupolyomavirusinfectioninbonemarrowtransplantrecipient
AT erdmandeand multiorganwupolyomavirusinfectioninbonemarrowtransplantrecipient
AT menegusmarilyna multiorganwupolyomavirusinfectioninbonemarrowtransplantrecipient
AT wangdavid multiorganwupolyomavirusinfectioninbonemarrowtransplantrecipient