Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis

BACKGROUND: We investigated sera from elderly subjects with and without age-related macular degeneration (AMD) for presence of autoantibodies (AAbs) against human macular antigens and characterized their identity. METHODS: Sera were collected from participants in the Age-Related Maculopathy Ancillar...

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Detalles Bibliográficos
Autores principales: Iannaccone, Alessandro, Giorgianni, Francesco, New, David D., Hollingsworth, T. J., Umfress, Allison, Alhatem, Albert H., Neeli, Indira, Lenchik, Nataliya I., Jennings, Barbara J., Calzada, Jorge I., Satterfield, Suzanne, Mathews, Dennis, Diaz, Rocio I., Harris, Tamara, Johnson, Karen C., Charles, Steve, Kritchevsky, Stephen B., Gerling, Ivan C., Beranova-Giorgianni, Sarka, Radic, Marko Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696815/
https://www.ncbi.nlm.nih.gov/pubmed/26717306
http://dx.doi.org/10.1371/journal.pone.0145323

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