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Burkholderia Sepsis in Children as a Hospital-Acquired Infection

PURPOSE: Hospital-acquired Burkholderia cepacia (B. cepacia) infection are not commonly recorded in patients without underlying lung disease, such as cystic fibrosis and chronic granulomatous disease. However, in 2014, B. cepacia appeared more frequently in pediatric blood samples than in any other...

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Autores principales: Kim, Kyu Yeun, Yong, Dongeun, Lee, Kyungwon, Kim, Ho-Seong, Kim, Dong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696978/
https://www.ncbi.nlm.nih.gov/pubmed/26632388
http://dx.doi.org/10.3349/ymj.2016.57.1.97
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author Kim, Kyu Yeun
Yong, Dongeun
Lee, Kyungwon
Kim, Ho-Seong
Kim, Dong Soo
author_facet Kim, Kyu Yeun
Yong, Dongeun
Lee, Kyungwon
Kim, Ho-Seong
Kim, Dong Soo
author_sort Kim, Kyu Yeun
collection PubMed
description PURPOSE: Hospital-acquired Burkholderia cepacia (B. cepacia) infection are not commonly recorded in patients without underlying lung disease, such as cystic fibrosis and chronic granulomatous disease. However, in 2014, B. cepacia appeared more frequently in pediatric blood samples than in any other year. In order to access this situation, we analyzed the clinical characteristics of B. cepacia infections in pediatric patients at our hospital. MATERIALS AND METHODS: We conducted a retrospective study of blood isolates of B. cepacia taken at our hospital between January 2004 and December 2014. Patient clinical data were obtained by retrospective review of electronic medical records. We constructed a dendrogram for B. cepacia isolates from two children and five adult patients. RESULTS: A total of 14 pediatric patients and 69 adult patients were identified as having B. cepacia bacteremia. In 2014, higher rates of B. cepacia bacteremia were observed in children. Most of them required Intensive Care Unit (ICU) care (12/14). In eleven children, sputum cultures were examined, and five of these children had the same strain of B. cepacia that grew out from their blood samples. Antibiotics were administered based on antibiotic sensitivity results. Four children expired despite treatment. Compared to children, there were no demonstrative differences in adults, except for history of ICU care. CONCLUSION: Although there were not many pediatric cases at our hospital, awareness of colonization through hospital-acquired infection and effective therapy for infection of B. cepacia is needed, as it can cause mortality and morbidity.
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spelling pubmed-46969782016-01-04 Burkholderia Sepsis in Children as a Hospital-Acquired Infection Kim, Kyu Yeun Yong, Dongeun Lee, Kyungwon Kim, Ho-Seong Kim, Dong Soo Yonsei Med J Original Article PURPOSE: Hospital-acquired Burkholderia cepacia (B. cepacia) infection are not commonly recorded in patients without underlying lung disease, such as cystic fibrosis and chronic granulomatous disease. However, in 2014, B. cepacia appeared more frequently in pediatric blood samples than in any other year. In order to access this situation, we analyzed the clinical characteristics of B. cepacia infections in pediatric patients at our hospital. MATERIALS AND METHODS: We conducted a retrospective study of blood isolates of B. cepacia taken at our hospital between January 2004 and December 2014. Patient clinical data were obtained by retrospective review of electronic medical records. We constructed a dendrogram for B. cepacia isolates from two children and five adult patients. RESULTS: A total of 14 pediatric patients and 69 adult patients were identified as having B. cepacia bacteremia. In 2014, higher rates of B. cepacia bacteremia were observed in children. Most of them required Intensive Care Unit (ICU) care (12/14). In eleven children, sputum cultures were examined, and five of these children had the same strain of B. cepacia that grew out from their blood samples. Antibiotics were administered based on antibiotic sensitivity results. Four children expired despite treatment. Compared to children, there were no demonstrative differences in adults, except for history of ICU care. CONCLUSION: Although there were not many pediatric cases at our hospital, awareness of colonization through hospital-acquired infection and effective therapy for infection of B. cepacia is needed, as it can cause mortality and morbidity. Yonsei University College of Medicine 2016-01-01 2015-11-30 /pmc/articles/PMC4696978/ /pubmed/26632388 http://dx.doi.org/10.3349/ymj.2016.57.1.97 Text en © Copyright: Yonsei University College of Medicine 2016 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Kyu Yeun
Yong, Dongeun
Lee, Kyungwon
Kim, Ho-Seong
Kim, Dong Soo
Burkholderia Sepsis in Children as a Hospital-Acquired Infection
title Burkholderia Sepsis in Children as a Hospital-Acquired Infection
title_full Burkholderia Sepsis in Children as a Hospital-Acquired Infection
title_fullStr Burkholderia Sepsis in Children as a Hospital-Acquired Infection
title_full_unstemmed Burkholderia Sepsis in Children as a Hospital-Acquired Infection
title_short Burkholderia Sepsis in Children as a Hospital-Acquired Infection
title_sort burkholderia sepsis in children as a hospital-acquired infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696978/
https://www.ncbi.nlm.nih.gov/pubmed/26632388
http://dx.doi.org/10.3349/ymj.2016.57.1.97
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