The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development

Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indic...

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Detalles Bibliográficos
Autores principales: Oh, Se-Yeong, Kim, Ju Young, Park, Changwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2015
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696993/
https://www.ncbi.nlm.nih.gov/pubmed/26694034
http://dx.doi.org/10.14348/molcells.2015.0331
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author Oh, Se-Yeong
Kim, Ju Young
Park, Changwon
author_facet Oh, Se-Yeong
Kim, Ju Young
Park, Changwon
author_sort Oh, Se-Yeong
collection PubMed
description Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indicate that ETV2, an ETS transcription factor, performs a potent and indispensable function in mediating vessel development. This review discusses the recent progress of the study of ETV2 with special focus on its regulatory mechanisms and cell fate determining role in developing mouse embryos as well as somatic cells.
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spelling pubmed-46969932016-01-12 The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development Oh, Se-Yeong Kim, Ju Young Park, Changwon Mol Cells Minireview Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indicate that ETV2, an ETS transcription factor, performs a potent and indispensable function in mediating vessel development. This review discusses the recent progress of the study of ETV2 with special focus on its regulatory mechanisms and cell fate determining role in developing mouse embryos as well as somatic cells. Korean Society for Molecular and Cellular Biology 2015-12-31 2015-12-21 /pmc/articles/PMC4696993/ /pubmed/26694034 http://dx.doi.org/10.14348/molcells.2015.0331 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Minireview
Oh, Se-Yeong
Kim, Ju Young
Park, Changwon
The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
title The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
title_full The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
title_fullStr The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
title_full_unstemmed The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
title_short The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
title_sort ets factor, etv2: a master regulator for vascular endothelial cell development
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696993/
https://www.ncbi.nlm.nih.gov/pubmed/26694034
http://dx.doi.org/10.14348/molcells.2015.0331
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