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Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease

INTRODUCTION: Both angiopoietins (angiopoietin 1 – Ang-1, angiopoietin 2 – Ang-2) and angiopoietin receptors (Tie) are involved in angiogenesis and vascular remodeling. AIM: To assess concentrations of Ang-1, Ang-2 and Tie-2 in blood of patients with chronic obstructive pulmonary disease (COPD) and...

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Autores principales: Kierszniewska-Stępień, Dorota, Pietras, Tadeusz, Ciebiada, Maciej, Górski, Paweł, Stępień, Henryk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697017/
https://www.ncbi.nlm.nih.gov/pubmed/26755908
http://dx.doi.org/10.5114/pdia.2014.44008
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author Kierszniewska-Stępień, Dorota
Pietras, Tadeusz
Ciebiada, Maciej
Górski, Paweł
Stępień, Henryk
author_facet Kierszniewska-Stępień, Dorota
Pietras, Tadeusz
Ciebiada, Maciej
Górski, Paweł
Stępień, Henryk
author_sort Kierszniewska-Stępień, Dorota
collection PubMed
description INTRODUCTION: Both angiopoietins (angiopoietin 1 – Ang-1, angiopoietin 2 – Ang-2) and angiopoietin receptors (Tie) are involved in angiogenesis and vascular remodeling. AIM: To assess concentrations of Ang-1, Ang-2 and Tie-2 in blood of patients with chronic obstructive pulmonary disease (COPD) and evaluate if their concentrations depend on the severity of the disease. MATERIAL AND METHODS: Thirty patients with COPD (stage II–IV) and 8 healthy smokers as well as 8 healthy non-smokers were included in the study. Detailed history was taken, physical examination and spirometry tests were done and blood samples were taken for evaluation of serum concentrations of Ang-1, Ang-2 and Tie. RESULTS: Among COPD patients, 8 patients suffered from moderate disease, 8 patients had severe, while 14 patients had very severe disease. The concentrations of Ang-1 and Ang-2 were not significantly greater in patients with COPD than in healthy controls. The highest concentrations of Ang-1 and Ang-2 were observed in patients with moderate COPD, and levels of Ang-2 correlated with Tie-2 in this group of patients. The levels of Ang-1 were the lowest in healthy non-smokers and in patients with severe COPD, where they inversely correlated with Tie-2. The concentrations of Ang-2 were not significantly higher in patients with moderate COPD when compared with those with severe and very severe disease and healthy smokers, and were significantly higher than in healthy non-smokers. CONCLUSIONS: It is possible that Ang-1, Ang-2 and Tie-2 play an important role especially in the early stage of COPD but not in the late phase when vascular complications of the disease occur.
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spelling pubmed-46970172016-01-11 Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease Kierszniewska-Stępień, Dorota Pietras, Tadeusz Ciebiada, Maciej Górski, Paweł Stępień, Henryk Postepy Dermatol Alergol Original Paper INTRODUCTION: Both angiopoietins (angiopoietin 1 – Ang-1, angiopoietin 2 – Ang-2) and angiopoietin receptors (Tie) are involved in angiogenesis and vascular remodeling. AIM: To assess concentrations of Ang-1, Ang-2 and Tie-2 in blood of patients with chronic obstructive pulmonary disease (COPD) and evaluate if their concentrations depend on the severity of the disease. MATERIAL AND METHODS: Thirty patients with COPD (stage II–IV) and 8 healthy smokers as well as 8 healthy non-smokers were included in the study. Detailed history was taken, physical examination and spirometry tests were done and blood samples were taken for evaluation of serum concentrations of Ang-1, Ang-2 and Tie. RESULTS: Among COPD patients, 8 patients suffered from moderate disease, 8 patients had severe, while 14 patients had very severe disease. The concentrations of Ang-1 and Ang-2 were not significantly greater in patients with COPD than in healthy controls. The highest concentrations of Ang-1 and Ang-2 were observed in patients with moderate COPD, and levels of Ang-2 correlated with Tie-2 in this group of patients. The levels of Ang-1 were the lowest in healthy non-smokers and in patients with severe COPD, where they inversely correlated with Tie-2. The concentrations of Ang-2 were not significantly higher in patients with moderate COPD when compared with those with severe and very severe disease and healthy smokers, and were significantly higher than in healthy non-smokers. CONCLUSIONS: It is possible that Ang-1, Ang-2 and Tie-2 play an important role especially in the early stage of COPD but not in the late phase when vascular complications of the disease occur. Termedia Publishing House 2015-12-11 2015-12 /pmc/articles/PMC4697017/ /pubmed/26755908 http://dx.doi.org/10.5114/pdia.2014.44008 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Kierszniewska-Stępień, Dorota
Pietras, Tadeusz
Ciebiada, Maciej
Górski, Paweł
Stępień, Henryk
Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease
title Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease
title_full Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease
title_fullStr Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease
title_full_unstemmed Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease
title_short Concentration of angiopoietins 1 and 2 and their receptor Tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease
title_sort concentration of angiopoietins 1 and 2 and their receptor tie-2 in peripheral blood in patients with chronic obstructive pulmonary disease
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697017/
https://www.ncbi.nlm.nih.gov/pubmed/26755908
http://dx.doi.org/10.5114/pdia.2014.44008
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