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Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant

Dengue virus (DENV) is the most common mosquito-transmitted virus infecting ~390 million people worldwide. In spite of this high medical relevance, neither a vaccine nor antiviral therapy is currently available. DENV elicits a strong interferon (IFN) response in infected cells, but at the same time...

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Detalles Bibliográficos
Autores principales:	Schmid, Bianca, Rinas, Melanie, Ruggieri, Alessia, Acosta, Eliana Gisela, Bartenschlager, Marie, Reuter, Antje, Fischl, Wolfgang, Harder, Nathalie, Bergeest, Jan-Philip, Flossdorf, Michael, Rohr, Karl, Höfer, Thomas, Bartenschlager, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697809/ https://www.ncbi.nlm.nih.gov/pubmed/26720415 http://dx.doi.org/10.1371/journal.ppat.1005345

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