Cargando…

Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals

Osteoporosis is a systemic disorder predominantly affecting postmenopausal women but also men at an advanced age. Both genders may suffer from low-energy fractures of, for example, the proximal humerus when reduction of the bone stock or/and quality has occurred. The aim of the current study was to...

Descripción completa

Detalles Bibliográficos
Autores principales: Sprecher, Christoph M., Schmidutz, Florian, Helfen, Tobias, Richards, R. Geoff, Blauth, Michael, Milz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697966/
https://www.ncbi.nlm.nih.gov/pubmed/26705200
http://dx.doi.org/10.1097/MD.0000000000002043
_version_ 1782408004254040064
author Sprecher, Christoph M.
Schmidutz, Florian
Helfen, Tobias
Richards, R. Geoff
Blauth, Michael
Milz, Stefan
author_facet Sprecher, Christoph M.
Schmidutz, Florian
Helfen, Tobias
Richards, R. Geoff
Blauth, Michael
Milz, Stefan
author_sort Sprecher, Christoph M.
collection PubMed
description Osteoporosis is a systemic disorder predominantly affecting postmenopausal women but also men at an advanced age. Both genders may suffer from low-energy fractures of, for example, the proximal humerus when reduction of the bone stock or/and quality has occurred. The aim of the current study was to compare the amount of bone in typical fracture zones of the proximal humerus in osteoporotic and non-osteoporotic individuals. The amount of bone in the proximal humerus was determined histomorphometrically in frontal plane sections. The donor bones were allocated to normal and osteoporotic groups using the T-score from distal radius DXA measurements of the same extremities. The T-score evaluation was done according to WHO criteria. Regional thickness of the subchondral plate and the metaphyseal cortical bone were measured using interactive image analysis. At all measured locations the amount of cancellous bone was significantly lower in individuals from the osteoporotic group compared to the non-osteoporotic one. The osteoporotic group showed more significant differences between regions of the same bone than the non-osteoporotic group. In both groups the subchondral cancellous bone and the subchondral plate were least affected by bone loss. In contrast, the medial metaphyseal region in the osteoporotic group exhibited higher bone loss in comparison to the lateral side. This observation may explain prevailing fracture patterns, which frequently involve compression fractures and certainly has an influence on the stability of implants placed in this medial region. It should be considered when planning the anchoring of osteosynthesis materials in osteoporotic patients with fractures of the proximal humerus.
format Online
Article
Text
id pubmed-4697966
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-46979662016-01-07 Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals Sprecher, Christoph M. Schmidutz, Florian Helfen, Tobias Richards, R. Geoff Blauth, Michael Milz, Stefan Medicine (Baltimore) 3200 Osteoporosis is a systemic disorder predominantly affecting postmenopausal women but also men at an advanced age. Both genders may suffer from low-energy fractures of, for example, the proximal humerus when reduction of the bone stock or/and quality has occurred. The aim of the current study was to compare the amount of bone in typical fracture zones of the proximal humerus in osteoporotic and non-osteoporotic individuals. The amount of bone in the proximal humerus was determined histomorphometrically in frontal plane sections. The donor bones were allocated to normal and osteoporotic groups using the T-score from distal radius DXA measurements of the same extremities. The T-score evaluation was done according to WHO criteria. Regional thickness of the subchondral plate and the metaphyseal cortical bone were measured using interactive image analysis. At all measured locations the amount of cancellous bone was significantly lower in individuals from the osteoporotic group compared to the non-osteoporotic one. The osteoporotic group showed more significant differences between regions of the same bone than the non-osteoporotic group. In both groups the subchondral cancellous bone and the subchondral plate were least affected by bone loss. In contrast, the medial metaphyseal region in the osteoporotic group exhibited higher bone loss in comparison to the lateral side. This observation may explain prevailing fracture patterns, which frequently involve compression fractures and certainly has an influence on the stability of implants placed in this medial region. It should be considered when planning the anchoring of osteosynthesis materials in osteoporotic patients with fractures of the proximal humerus. Wolters Kluwer Health 2015-12-28 /pmc/articles/PMC4697966/ /pubmed/26705200 http://dx.doi.org/10.1097/MD.0000000000002043 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 3200
Sprecher, Christoph M.
Schmidutz, Florian
Helfen, Tobias
Richards, R. Geoff
Blauth, Michael
Milz, Stefan
Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals
title Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals
title_full Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals
title_fullStr Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals
title_full_unstemmed Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals
title_short Histomorphometric Assessment of Cancellous and Cortical Bone Material Distribution in the Proximal Humerus of Normal and Osteoporotic Individuals: Significantly Reduced Bone Stock in the Metaphyseal and Subcapital Regions of Osteoporotic Individuals
title_sort histomorphometric assessment of cancellous and cortical bone material distribution in the proximal humerus of normal and osteoporotic individuals: significantly reduced bone stock in the metaphyseal and subcapital regions of osteoporotic individuals
topic 3200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697966/
https://www.ncbi.nlm.nih.gov/pubmed/26705200
http://dx.doi.org/10.1097/MD.0000000000002043
work_keys_str_mv AT sprecherchristophm histomorphometricassessmentofcancellousandcorticalbonematerialdistributionintheproximalhumerusofnormalandosteoporoticindividualssignificantlyreducedbonestockinthemetaphysealandsubcapitalregionsofosteoporoticindividuals
AT schmidutzflorian histomorphometricassessmentofcancellousandcorticalbonematerialdistributionintheproximalhumerusofnormalandosteoporoticindividualssignificantlyreducedbonestockinthemetaphysealandsubcapitalregionsofosteoporoticindividuals
AT helfentobias histomorphometricassessmentofcancellousandcorticalbonematerialdistributionintheproximalhumerusofnormalandosteoporoticindividualssignificantlyreducedbonestockinthemetaphysealandsubcapitalregionsofosteoporoticindividuals
AT richardsrgeoff histomorphometricassessmentofcancellousandcorticalbonematerialdistributionintheproximalhumerusofnormalandosteoporoticindividualssignificantlyreducedbonestockinthemetaphysealandsubcapitalregionsofosteoporoticindividuals
AT blauthmichael histomorphometricassessmentofcancellousandcorticalbonematerialdistributionintheproximalhumerusofnormalandosteoporoticindividualssignificantlyreducedbonestockinthemetaphysealandsubcapitalregionsofosteoporoticindividuals
AT milzstefan histomorphometricassessmentofcancellousandcorticalbonematerialdistributionintheproximalhumerusofnormalandosteoporoticindividualssignificantlyreducedbonestockinthemetaphysealandsubcapitalregionsofosteoporoticindividuals