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Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2
Atherosclerosis is a dise ase characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins, those may lead to acute coronary syndrome (ACS). We investigated...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698373/ https://www.ncbi.nlm.nih.gov/pubmed/25179298 http://dx.doi.org/10.1007/s00380-014-0565-9 |
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author | Satoh, Shinji Yada, Ryoko Inoue, Hiroko Omura, Soichiro Ejima, Emiko Mori, Takahiro Takenaka, Katsuhiko Kawamura, Natsumi Numaguchi, Kotaro Mori, Etsuo Asoh, Akemi Nakamura, Toshihiro Hiyamuta, Koji |
author_facet | Satoh, Shinji Yada, Ryoko Inoue, Hiroko Omura, Soichiro Ejima, Emiko Mori, Takahiro Takenaka, Katsuhiko Kawamura, Natsumi Numaguchi, Kotaro Mori, Etsuo Asoh, Akemi Nakamura, Toshihiro Hiyamuta, Koji |
author_sort | Satoh, Shinji |
collection | PubMed |
description | Atherosclerosis is a dise ase characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins, those may lead to acute coronary syndrome (ACS). We investigated the expression level of TLR-4 in ACS, as compared with TLR-2 and patients with stable angina. Fifty-eight consecutive patients who underwent primary percutaneous coronary intervention (PCI, n = 29) because of ACS and elective PCI (n = 29) because of stable angina using a filter-device distal protection device system were prospectively analyzed. mRNA levels of TLR-2 and TLR-4 in debris containing various inflammatory tissues entrapped in the filter device were altogether analyzed using real-time PCR. There were no significant differences in age, sex distribution, between stable angina and ACS groups. TLR-4 expression levels were higher in patients with ACS than in patients with stable angina. TLR-4 might play a more important role than TLR-2 in atherogenesis, especially in ACS. |
format | Online Article Text |
id | pubmed-4698373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-46983732016-01-08 Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2 Satoh, Shinji Yada, Ryoko Inoue, Hiroko Omura, Soichiro Ejima, Emiko Mori, Takahiro Takenaka, Katsuhiko Kawamura, Natsumi Numaguchi, Kotaro Mori, Etsuo Asoh, Akemi Nakamura, Toshihiro Hiyamuta, Koji Heart Vessels Original Article Atherosclerosis is a dise ase characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins, those may lead to acute coronary syndrome (ACS). We investigated the expression level of TLR-4 in ACS, as compared with TLR-2 and patients with stable angina. Fifty-eight consecutive patients who underwent primary percutaneous coronary intervention (PCI, n = 29) because of ACS and elective PCI (n = 29) because of stable angina using a filter-device distal protection device system were prospectively analyzed. mRNA levels of TLR-2 and TLR-4 in debris containing various inflammatory tissues entrapped in the filter device were altogether analyzed using real-time PCR. There were no significant differences in age, sex distribution, between stable angina and ACS groups. TLR-4 expression levels were higher in patients with ACS than in patients with stable angina. TLR-4 might play a more important role than TLR-2 in atherogenesis, especially in ACS. Springer Japan 2014-09-02 2016 /pmc/articles/PMC4698373/ /pubmed/25179298 http://dx.doi.org/10.1007/s00380-014-0565-9 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Satoh, Shinji Yada, Ryoko Inoue, Hiroko Omura, Soichiro Ejima, Emiko Mori, Takahiro Takenaka, Katsuhiko Kawamura, Natsumi Numaguchi, Kotaro Mori, Etsuo Asoh, Akemi Nakamura, Toshihiro Hiyamuta, Koji Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2 |
title | Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2 |
title_full | Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2 |
title_fullStr | Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2 |
title_full_unstemmed | Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2 |
title_short | Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2 |
title_sort | toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than toll-like receptor-2 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698373/ https://www.ncbi.nlm.nih.gov/pubmed/25179298 http://dx.doi.org/10.1007/s00380-014-0565-9 |
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