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Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women

A reduction in exercise efficiency with aging limits daily living activities. We examined whether 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) increased exercise efficiency and voluntary achievement of interval walking training (IWT) in older women. Ten women [65 ± 3(SD) yr] who had...

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Autores principales: Masuki, Shizue, Morita, Atsumi, Kamijo, Yoshi-ichiro, Ikegawa, Shigeki, Kataoka, Yufuko, Ogawa, Yu, Sumiyoshi, Eri, Takahashi, Kiwamu, Tanaka, Tohru, Nakajima, Motowo, Nose, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698441/
https://www.ncbi.nlm.nih.gov/pubmed/26514619
http://dx.doi.org/10.1152/japplphysiol.00582.2015
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author Masuki, Shizue
Morita, Atsumi
Kamijo, Yoshi-ichiro
Ikegawa, Shigeki
Kataoka, Yufuko
Ogawa, Yu
Sumiyoshi, Eri
Takahashi, Kiwamu
Tanaka, Tohru
Nakajima, Motowo
Nose, Hiroshi
author_facet Masuki, Shizue
Morita, Atsumi
Kamijo, Yoshi-ichiro
Ikegawa, Shigeki
Kataoka, Yufuko
Ogawa, Yu
Sumiyoshi, Eri
Takahashi, Kiwamu
Tanaka, Tohru
Nakajima, Motowo
Nose, Hiroshi
author_sort Masuki, Shizue
collection PubMed
description A reduction in exercise efficiency with aging limits daily living activities. We examined whether 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) increased exercise efficiency and voluntary achievement of interval walking training (IWT) in older women. Ten women [65 ± 3(SD) yr] who had performed IWT for >12 mo and were currently performing IWT participated in this study. The study was conducted in a placebo-controlled, double-blind crossover design. All subjects underwent two trials for 7 days each in which they performed IWT with ALA+SFC (100 and 115 mg/day, respectively) or placebo supplement intake (CNT), intermittently with a 2-wk washout period. Before and after each trial, subjects underwent a graded cycling test at 27.0°C atmospheric temperature and 50% relative humidity, and oxygen consumption rate, carbon dioxide production rate, and lactate concentration in plasma were measured. Furthermore, for the first 6 days of each trial, exercise intensity for IWT was measured by accelerometry. We found that, in the ALA+SFC trial, oxygen consumption rate and carbon dioxide production rate during graded cycling decreased by 12% (P < 0.001) and 11% (P = 0.001) at every workload, respectively, accompanied by a 16% reduction in lactate concentration in plasma (P < 0.001), although all remained unchanged in the CNT trial (P > 0.2). All of the reductions were significantly greater in the ALA+SFC than the CNT trial (P < 0.05). Furthermore, the training days, impulse, and time at fast walking were 42% (P = 0.028), 102% (P = 0.027), and 69% (P = 0.039) higher during the ALA+SFC than the CNT intake period, respectively. Thus ALA+SFC supplementation augmented exercise efficiency and thereby improved IWT achievement in older women.
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spelling pubmed-46984412016-01-13 Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women Masuki, Shizue Morita, Atsumi Kamijo, Yoshi-ichiro Ikegawa, Shigeki Kataoka, Yufuko Ogawa, Yu Sumiyoshi, Eri Takahashi, Kiwamu Tanaka, Tohru Nakajima, Motowo Nose, Hiroshi J Appl Physiol (1985) Articles A reduction in exercise efficiency with aging limits daily living activities. We examined whether 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) increased exercise efficiency and voluntary achievement of interval walking training (IWT) in older women. Ten women [65 ± 3(SD) yr] who had performed IWT for >12 mo and were currently performing IWT participated in this study. The study was conducted in a placebo-controlled, double-blind crossover design. All subjects underwent two trials for 7 days each in which they performed IWT with ALA+SFC (100 and 115 mg/day, respectively) or placebo supplement intake (CNT), intermittently with a 2-wk washout period. Before and after each trial, subjects underwent a graded cycling test at 27.0°C atmospheric temperature and 50% relative humidity, and oxygen consumption rate, carbon dioxide production rate, and lactate concentration in plasma were measured. Furthermore, for the first 6 days of each trial, exercise intensity for IWT was measured by accelerometry. We found that, in the ALA+SFC trial, oxygen consumption rate and carbon dioxide production rate during graded cycling decreased by 12% (P < 0.001) and 11% (P = 0.001) at every workload, respectively, accompanied by a 16% reduction in lactate concentration in plasma (P < 0.001), although all remained unchanged in the CNT trial (P > 0.2). All of the reductions were significantly greater in the ALA+SFC than the CNT trial (P < 0.05). Furthermore, the training days, impulse, and time at fast walking were 42% (P = 0.028), 102% (P = 0.027), and 69% (P = 0.039) higher during the ALA+SFC than the CNT intake period, respectively. Thus ALA+SFC supplementation augmented exercise efficiency and thereby improved IWT achievement in older women. American Physiological Society 2015-10-29 2016-01-01 /pmc/articles/PMC4698441/ /pubmed/26514619 http://dx.doi.org/10.1152/japplphysiol.00582.2015 Text en Copyright © 2016 the American Physiological Society http://creativecommons.org/licenses/by/3.0/deed.en_US Licensed under Creative Commons Attribution CC-BY 3.0 (http://creativecommons.org/licenses/by/3.0/deed.en_US) : © the American Physiological Society.
spellingShingle Articles
Masuki, Shizue
Morita, Atsumi
Kamijo, Yoshi-ichiro
Ikegawa, Shigeki
Kataoka, Yufuko
Ogawa, Yu
Sumiyoshi, Eri
Takahashi, Kiwamu
Tanaka, Tohru
Nakajima, Motowo
Nose, Hiroshi
Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women
title Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women
title_full Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women
title_fullStr Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women
title_full_unstemmed Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women
title_short Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women
title_sort impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698441/
https://www.ncbi.nlm.nih.gov/pubmed/26514619
http://dx.doi.org/10.1152/japplphysiol.00582.2015
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