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Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers
Radiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698596/ https://www.ncbi.nlm.nih.gov/pubmed/26779314 http://dx.doi.org/10.4081/oncol.2015.290 |
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author | Jayakrishnan, Ritujith Chang, Kenneth Ugurluer, Gamze Miller, Robert C. Sio, Terence T. |
author_facet | Jayakrishnan, Ritujith Chang, Kenneth Ugurluer, Gamze Miller, Robert C. Sio, Terence T. |
author_sort | Jayakrishnan, Ritujith |
collection | PubMed |
description | Radiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving cancer cure. Conventionally, RT-induced OM pain is treated with analgesics and/or mouthwash rinses. Doxepin, a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa, has been shown to lower OM pain in multiple single-arm trials (Epstein et al.) and more recently, in a placebo-controlled crossover study (Leenstra and Miller et al.). Currently, a placebo-controlled study (Sio and Miller et al.) using doxepin for esophagitis pain caused by RT to the thorax is underway. Doxepin will also be further compared with magic mouthwash and a placebo solution in a three-arm trial (Miller and Sio et al.) with head and neck cancer patients with OM pain caused by RT. Doxepin may represent a new standard for treating RT-induced OM pain in the future. |
format | Online Article Text |
id | pubmed-4698596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-46985962016-01-15 Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers Jayakrishnan, Ritujith Chang, Kenneth Ugurluer, Gamze Miller, Robert C. Sio, Terence T. Oncol Rev Editorial Radiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving cancer cure. Conventionally, RT-induced OM pain is treated with analgesics and/or mouthwash rinses. Doxepin, a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa, has been shown to lower OM pain in multiple single-arm trials (Epstein et al.) and more recently, in a placebo-controlled crossover study (Leenstra and Miller et al.). Currently, a placebo-controlled study (Sio and Miller et al.) using doxepin for esophagitis pain caused by RT to the thorax is underway. Doxepin will also be further compared with magic mouthwash and a placebo solution in a three-arm trial (Miller and Sio et al.) with head and neck cancer patients with OM pain caused by RT. Doxepin may represent a new standard for treating RT-induced OM pain in the future. PAGEPress Publications, Pavia, Italy 2015-12-09 /pmc/articles/PMC4698596/ /pubmed/26779314 http://dx.doi.org/10.4081/oncol.2015.290 Text en ©Copyright R. Jayakrishnan et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Editorial Jayakrishnan, Ritujith Chang, Kenneth Ugurluer, Gamze Miller, Robert C. Sio, Terence T. Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers |
title | Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers |
title_full | Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers |
title_fullStr | Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers |
title_full_unstemmed | Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers |
title_short | Doxepin for Radiation Therapy-Induced Mucositis Pain in the Treatment of Oral Cancers |
title_sort | doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698596/ https://www.ncbi.nlm.nih.gov/pubmed/26779314 http://dx.doi.org/10.4081/oncol.2015.290 |
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