Arsenic-induced Histological Alterations in Various Organs of Mice

Deposition of arsenic in mice through groundwater is well documented but little is known about the histological changes of organs by the metalloid. Present study was designed to evaluate arsenic-induced histological alterations in kidney, liver, thoracic artery and brain of mice which are not well d...

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Detalles Bibliográficos
Autores principales: Noman, Abu Shadat Mohammod, Dilruba, Sayada, Mohanto, Nayan Chandra, Rahman, Lutfur, Khatun, Zohora, Riad, Wahiduzzaman, Al Mamun, Abdullah, Alam, Shahnur, Aktar, Sharmin, Chowdhury, Srikanta, Saud, Zahangir Alam, Rahman, Zillur, Hossain, Khaled, Haque, Azizul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698904/
https://www.ncbi.nlm.nih.gov/pubmed/26740907
http://dx.doi.org/10.4172/2157-7099.1000323
Descripción
Sumario:Deposition of arsenic in mice through groundwater is well documented but little is known about the histological changes of organs by the metalloid. Present study was designed to evaluate arsenic-induced histological alterations in kidney, liver, thoracic artery and brain of mice which are not well documented yet. Swiss albino male mice were divided into 2 groups and treated as follows: Group 1: control, 2: arsenic (sodium arsenite at 10 mg/kg b.w. orally for 8 wks). Group 2 showed marked degenerative changes in kidney, liver, thoracic artery, and brain whereas Group 1 did not reveal any abnormalities on histopathology. We therefore concluded that arsenic induces histological alterations in the tested organs.

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