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Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet
We show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699013/ https://www.ncbi.nlm.nih.gov/pubmed/26798426 http://dx.doi.org/10.1155/2016/6929306 |
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author | Zhang, Guangyin Li, Ming Xu, Yinzhi Peng, Li Yang, Cui Zhou, Yanan Zhang, Junping |
author_facet | Zhang, Guangyin Li, Ming Xu, Yinzhi Peng, Li Yang, Cui Zhou, Yanan Zhang, Junping |
author_sort | Zhang, Guangyin |
collection | PubMed |
description | We show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify HO-1 and other related antioxidant enzymes as molecular target for active redox compounds. Second, our experiments have pointed out an association between statin treatment and a decrease in the risk of having peroxidation damage of brain. The balance effects of simvastatin to ROS and antioxidants enzymes network are most probably due to improved SOD functional activity, increase in GSH-Px, increase in HO-1 expression, and decrease of MDA generation. |
format | Online Article Text |
id | pubmed-4699013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46990132016-01-21 Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet Zhang, Guangyin Li, Ming Xu, Yinzhi Peng, Li Yang, Cui Zhou, Yanan Zhang, Junping Oxid Med Cell Longev Research Article We show that hypercholesterolemia contributes to oxidative stress injury progression in brain and simvastatin counteracts the cholesterol-induced peroxidation injury in rabbit hippocampus, and we demonstrate for the first time that the simvastatin is a critical role in brain protection and identify HO-1 and other related antioxidant enzymes as molecular target for active redox compounds. Second, our experiments have pointed out an association between statin treatment and a decrease in the risk of having peroxidation damage of brain. The balance effects of simvastatin to ROS and antioxidants enzymes network are most probably due to improved SOD functional activity, increase in GSH-Px, increase in HO-1 expression, and decrease of MDA generation. Hindawi Publishing Corporation 2016 2015-12-20 /pmc/articles/PMC4699013/ /pubmed/26798426 http://dx.doi.org/10.1155/2016/6929306 Text en Copyright © 2016 Guangyin Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Guangyin Li, Ming Xu, Yinzhi Peng, Li Yang, Cui Zhou, Yanan Zhang, Junping Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title | Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_full | Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_fullStr | Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_full_unstemmed | Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_short | Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet |
title_sort | antioxidation effect of simvastatin in aorta and hippocampus: a rabbit model fed high-cholesterol diet |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699013/ https://www.ncbi.nlm.nih.gov/pubmed/26798426 http://dx.doi.org/10.1155/2016/6929306 |
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