Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats

Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rat...

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Detalles Bibliográficos
Autores principales: Chen, Qing-Ying, Wang, Guo-Guang, Li, Wei, Jiang, Yu-Xin, Lu, Xiao-Hua, Zhou, Ping-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699015/
https://www.ncbi.nlm.nih.gov/pubmed/26798657
http://dx.doi.org/10.1155/2016/9726503
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author Chen, Qing-Ying
Wang, Guo-Guang
Li, Wei
Jiang, Yu-Xin
Lu, Xiao-Hua
Zhou, Ping-Ping
author_facet Chen, Qing-Ying
Wang, Guo-Guang
Li, Wei
Jiang, Yu-Xin
Lu, Xiao-Hua
Zhou, Ping-Ping
author_sort Chen, Qing-Ying
collection PubMed
description Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.
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spelling pubmed-46990152016-01-21 Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats Chen, Qing-Ying Wang, Guo-Guang Li, Wei Jiang, Yu-Xin Lu, Xiao-Hua Zhou, Ping-Ping J Diabetes Res Research Article Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats. Hindawi Publishing Corporation 2016 2015-12-20 /pmc/articles/PMC4699015/ /pubmed/26798657 http://dx.doi.org/10.1155/2016/9726503 Text en Copyright © 2016 Qing-Ying Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Qing-Ying
Wang, Guo-Guang
Li, Wei
Jiang, Yu-Xin
Lu, Xiao-Hua
Zhou, Ping-Ping
Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
title Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
title_full Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
title_fullStr Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
title_full_unstemmed Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
title_short Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
title_sort heme oxygenase-1 promotes delayed wound healing in diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699015/
https://www.ncbi.nlm.nih.gov/pubmed/26798657
http://dx.doi.org/10.1155/2016/9726503
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