Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (1–5), were isolated from the octocoral Briareum sp. The structures of briaranes 1–5 were elucidated by spectroscopic methods. Briarenolides U–Y (1–5) were found to significantly inhibit the expression of the pro-inflammatory inducible nit...

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Autores principales: Su, Yin-Di, Wu, Tung-Ying, Wen, Zhi-Hong, Su, Ching-Chyuan, Chen, Yu-Hsin, Chang, Yu-Chia, Wu, Yang-Chang, Sheu, Jyh-Horng, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699233/
https://www.ncbi.nlm.nih.gov/pubmed/26633428
http://dx.doi.org/10.3390/md13127060
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author Su, Yin-Di
Wu, Tung-Ying
Wen, Zhi-Hong
Su, Ching-Chyuan
Chen, Yu-Hsin
Chang, Yu-Chia
Wu, Yang-Chang
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_facet Su, Yin-Di
Wu, Tung-Ying
Wen, Zhi-Hong
Su, Ching-Chyuan
Chen, Yu-Hsin
Chang, Yu-Chia
Wu, Yang-Chang
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_sort Su, Yin-Di
collection PubMed
description Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (1–5), were isolated from the octocoral Briareum sp. The structures of briaranes 1–5 were elucidated by spectroscopic methods. Briarenolides U–Y (1–5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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spelling pubmed-46992332016-01-21 Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae) Su, Yin-Di Wu, Tung-Ying Wen, Zhi-Hong Su, Ching-Chyuan Chen, Yu-Hsin Chang, Yu-Chia Wu, Yang-Chang Sheu, Jyh-Horng Sung, Ping-Jyun Mar Drugs Article Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (1–5), were isolated from the octocoral Briareum sp. The structures of briaranes 1–5 were elucidated by spectroscopic methods. Briarenolides U–Y (1–5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. MDPI 2015-12-03 /pmc/articles/PMC4699233/ /pubmed/26633428 http://dx.doi.org/10.3390/md13127060 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Yin-Di
Wu, Tung-Ying
Wen, Zhi-Hong
Su, Ching-Chyuan
Chen, Yu-Hsin
Chang, Yu-Chia
Wu, Yang-Chang
Sheu, Jyh-Horng
Sung, Ping-Jyun
Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_full Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_fullStr Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_full_unstemmed Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_short Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_sort briarenolides u–y, new anti-inflammatory briarane diterpenoids from an octocoral briareum sp. (briareidae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699233/
https://www.ncbi.nlm.nih.gov/pubmed/26633428
http://dx.doi.org/10.3390/md13127060
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