High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction

BACKGROUND: Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to assay blood DNA methylation at approximately 4.5 million loci, each comprising 2.9 CpGs on average, in 697 normal subjects. Methylat...

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Detalles Bibliográficos
Autores principales: McClay, Joseph L., Shabalin, Andrey A., Dozmorov, Mikhail G., Adkins, Daniel E., Kumar, Gaurav, Nerella, Srilaxmi, Clark, Shaunna L., Bergen, Sarah E., Hultman, Christina M., Magnusson, Patrik K. E., Sullivan, Patrick F., Aberg, Karolina A., van den Oord, Edwin J. C. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699364/
https://www.ncbi.nlm.nih.gov/pubmed/26699738
http://dx.doi.org/10.1186/s13059-015-0842-7

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