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The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation

The Brr2 helicase provides the key remodeling activity for spliceosome catalytic activation, during which it disrupts the U4/U6 di-snRNP (small nuclear RNA protein), and its activity has to be tightly regulated. Brr2 exhibits an unusual architecture, including an ∼500-residue N-terminal region, whos...

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Detalles Bibliográficos
Autores principales:	Absmeier, Eva, Wollenhaupt, Jan, Mozaffari-Jovin, Sina, Becke, Christian, Lee, Chung-Tien, Preussner, Marco, Heyd, Florian, Urlaub, Henning, Lührmann, Reinhard, Santos, Karine F., Wahl, Markus C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699386/ https://www.ncbi.nlm.nih.gov/pubmed/26637280 http://dx.doi.org/10.1101/gad.271528.115

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