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Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans
Sleep, specifically non-rapid eye movement (NREM) sleep, is thought to play a critical role in the consolidation of recent memories. Two main oscillatory activities observed during NREM, cortical slow oscillations (SO, 0.5–1.0Hz) and thalamic spindles (12–15Hz), have been shown to independently corr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699460/ https://www.ncbi.nlm.nih.gov/pubmed/26671283 http://dx.doi.org/10.1371/journal.pone.0144720 |
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author | Niknazar, Mohammad Krishnan, Giri P. Bazhenov, Maxim Mednick, Sara C. |
author_facet | Niknazar, Mohammad Krishnan, Giri P. Bazhenov, Maxim Mednick, Sara C. |
author_sort | Niknazar, Mohammad |
collection | PubMed |
description | Sleep, specifically non-rapid eye movement (NREM) sleep, is thought to play a critical role in the consolidation of recent memories. Two main oscillatory activities observed during NREM, cortical slow oscillations (SO, 0.5–1.0Hz) and thalamic spindles (12–15Hz), have been shown to independently correlate with memory improvement. Yet, it is not known how these thalamocortical events interact, or the significance of this interaction, during the consolidation process. Here, we found that systemic administration of the GABAergic drug (zolpidem) increased both the phase-amplitude coupling between SO and spindles, and verbal memory improvement in humans. These results suggest that thalamic spindles that occur during transitions to the cortical SO Up state are optimal for memory consolidation. Our study predicts that the timely interactions between cortical and thalamic events during consolidation, contribute to memory improvement and is mediated by the level of inhibitory neurotransmission. |
format | Online Article Text |
id | pubmed-4699460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46994602016-01-14 Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans Niknazar, Mohammad Krishnan, Giri P. Bazhenov, Maxim Mednick, Sara C. PLoS One Research Article Sleep, specifically non-rapid eye movement (NREM) sleep, is thought to play a critical role in the consolidation of recent memories. Two main oscillatory activities observed during NREM, cortical slow oscillations (SO, 0.5–1.0Hz) and thalamic spindles (12–15Hz), have been shown to independently correlate with memory improvement. Yet, it is not known how these thalamocortical events interact, or the significance of this interaction, during the consolidation process. Here, we found that systemic administration of the GABAergic drug (zolpidem) increased both the phase-amplitude coupling between SO and spindles, and verbal memory improvement in humans. These results suggest that thalamic spindles that occur during transitions to the cortical SO Up state are optimal for memory consolidation. Our study predicts that the timely interactions between cortical and thalamic events during consolidation, contribute to memory improvement and is mediated by the level of inhibitory neurotransmission. Public Library of Science 2015-12-15 /pmc/articles/PMC4699460/ /pubmed/26671283 http://dx.doi.org/10.1371/journal.pone.0144720 Text en © 2015 Niknazar et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Niknazar, Mohammad Krishnan, Giri P. Bazhenov, Maxim Mednick, Sara C. Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans |
title | Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans |
title_full | Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans |
title_fullStr | Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans |
title_full_unstemmed | Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans |
title_short | Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans |
title_sort | coupling of thalamocortical sleep oscillations are important for memory consolidation in humans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699460/ https://www.ncbi.nlm.nih.gov/pubmed/26671283 http://dx.doi.org/10.1371/journal.pone.0144720 |
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