Cargando…

Polymorphs of Theophylline Characterized by DNP Enhanced Solid-State NMR

[Image: see text] We show how dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy can be used to characterize polymorphs and solvates of organic solids. We applied DNP to three polymorphs and one hydrated form of the asthma drug molecule theophylline. For some forms of theophyll...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pinon, Arthur C., Rossini, Aaron J., Widdifield, Cory M., Gajan, David, Emsley, Lyndon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699642/ https://www.ncbi.nlm.nih.gov/pubmed/26393368 http://dx.doi.org/10.1021/acs.molpharmaceut.5b00610

Ejemplares similares

Targeted DNP for biomolecular solid-state NMR
por: Gauto, Diego, et al.
Publicado: (2021)

Hierarchy of the Components in Spray-Dried, Protein-Excipient Particles Using DNP-Enhanced NMR Spectroscopy
por: Berruyer, Pierrick, et al.
Publicado: (2023)

Polarizing agents for efficient high field DNP solid-state NMR spectroscopy under magic-angle spinning: from design principles to formulation strategies
por: Menzildjian, Georges, et al.
Publicado: (2023)

Dendritic polarizing agents for DNP SENS
por: Liao, Wei-Chih, et al.
Publicado: (2017)

DNP‐Supported Solid‐State NMR Spectroscopy of Proteins Inside Mammalian Cells
por: Narasimhan, Siddarth, et al.
Publicado: (2019)

Optically Enhanced Solid-State (1)H NMR Spectroscopy
por: De Biasi, Federico, et al.
Publicado: (2023)

Colloidal-ALD-Grown Core/Shell CdSe/CdS Nanoplatelets as Seen by DNP Enhanced PASS–PIETA NMR Spectroscopy
por: Piveteau, Laura, et al.
Publicado: (2020)

Rapid Structure Determination of Molecular Solids Using Chemical Shifts Directed by Unambiguous Prior Constraints
por: Hofstetter, Albert, et al.
Publicado: (2019)

Probing the photointermediates of light-driven sodium ion pump KR2 by DNP-enhanced solid-state NMR
por: Jakdetchai, Orawan, et al.
Publicado: (2021)

Predicting the DNP-SENS efficiency in reactive heterogeneous catalysts from hydrophilicity
por: Pump, Eva, et al.
Publicado: (2018)

Solid-State Dynamic Nuclear Polarization at 9.4 and 18.8 T from 100 K to Room Temperature
por: Lelli, Moreno, et al.
Publicado: (2015)

Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
por: Kiss, Sebastian Z., et al.
Publicado: (2021)

Atomic-level structure determination of amorphous molecular solids by NMR
por: Cordova, Manuel, et al.
Publicado: (2023)

DNP-Enhanced MAS NMR of Bovine Serum Albumin Sediments and Solutions
por: Ravera, Enrico, et al.
Publicado: (2014)

Selective high-resolution DNP-enhanced NMR of biomolecular binding sites
por: Marin-Montesinos, Ildefonso, et al.
Publicado: (2019)

A high-field cellular DNP-supported solid-state NMR approach to study proteins with sub-cellular specificity
por: Beriashvili, David, et al.
Publicado: (2023)

DNP-Enhanced MAS NMR: A Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States
por: Uluca, Boran, et al.
Publicado: (2018)

A Complete Picture of Cation Dynamics in Hybrid Perovskite Materials from Solid-State NMR Spectroscopy
por: Mishra, Aditya, et al.
Publicado: (2022)

Welcoming natural isotopic abundance in solid-state NMR: probing π-stacking and supramolecular structure of organic nanoassemblies using DNP
por: Märker, Katharina, et al.
Publicado: (2017)

Three-Dimensional Structure Determination of Surface Sites
por: Berruyer, Pierrick, et al.
Publicado: (2016)

Exploiting solid-state dynamic nuclear polarization NMR spectroscopy to establish the spatial distribution of polymorphic phases in a solid material
por: Cousin, Samuel F., et al.
Publicado: (2023)

An Enhanced Actualized DNP Model to Improve DNP Project Placements, Rigor, and Completion
por: VanderKooi, Marie E., et al.
Publicado: (2018)

A monoclinic polymorph of theophylline
por: Zhang, Shuo, et al.
Publicado: (2011)

Homonuclear Decoupling in (1)H NMR of Solids by Remote Correlation
por: Moutzouri, Pinelopi, et al.
Publicado: (2020)

Structural characterization of tin in toothpaste by dynamic nuclear polarization enhanced (119)Sn solid-state NMR spectroscopy
por: Dorn, Rick W., et al.
Publicado: (2023)

In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide
por: Separovic, Frances, et al.
Publicado: (2022)

Pure Isotropic Proton NMR Spectra in Solids using Deep Learning
por: Cordova, Manuel, et al.
Publicado: (2023)

Donor–acceptor stacking arrangements in bulk and thin-film high-mobility conjugated polymers characterized using molecular modelling and MAS and surface-enhanced solid-state NMR spectroscopy
por: Chaudhari, Sachin R., et al.
Publicado: (2017)

DNP 2017
Publicado: (2017)

DNP NMR spectroscopy enabled direct characterization of polystyrene-supported catalyst species for synthesis of glycidyl esters by transesterification
por: Tanaka, Shinji, et al.
Publicado: (2022)

Reactive surface organometallic complexes observed using dynamic nuclear polarization surface enhanced NMR spectroscopy
por: Pump, Eva, et al.
Publicado: (2017)

Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR
por: Lange, Sascha, et al.
Publicado: (2016)

Transportable hyperpolarized metabolites
por: Ji, Xiao, et al.
Publicado: (2017)

Local Structure and Dynamics in Methylammonium, Formamidinium, and Cesium Tin(II) Mixed-Halide Perovskites from (119)Sn Solid-State NMR
por: Kubicki, Dominik J., et al.
Publicado: (2020)

Theophylline
por: Barnes, Peter J.
Publicado: (2010)

Electroplated waveguides to enhance DNP and EPR spectra of silicon and diamond particles
por: Himmler, Aaron, et al.
Publicado: (2022)

Structural analysis of cross-linked poly(vinyl alcohol) using high-field DNP-NMR
por: Kanda, Taiji, et al.
Publicado: (2020)

Phase Segregation in Cs-, Rb- and K-Doped Mixed-Cation (MA)(x)(FA)(1–x)PbI(3) Hybrid Perovskites from Solid-State NMR
por: Kubicki, Dominik J., et al.
Publicado: (2017)

One- and Two-Dimensional High-Resolution NMR from Flat Surfaces
por: Walder, Brennan J., et al.
Publicado: (2019)

In-Cell NMR of Intact Mammalian Cells Preserved with the Cryoprotectants DMSO and Glycerol Have Similar DNP Performance
por: Xiao, Yiling, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v4g68feabr7uc1pgb0n8dst8tm