The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability

DNA polymerase ζ (pol ζ) is exceptionally important for maintaining genome stability. Inactivation of the Rev3l gene encoding the polymerase catalytic subunit causes a high frequency of chromosomal breaks, followed by lethality in mouse embryos and in primary cells. Yet it is not known whether the D...

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Detalles Bibliográficos
Autores principales: Lange, Sabine S., Tomida, Junya, Boulware, Karen S., Bhetawal, Sarita, Wood, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699697/
https://www.ncbi.nlm.nih.gov/pubmed/26727495
http://dx.doi.org/10.1371/journal.pgen.1005759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699697/
https://www.ncbi.nlm.nih.gov/pubmed/26727495
http://dx.doi.org/10.1371/journal.pgen.1005759

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