The selenium content of SEPP1 versus selenium requirements in vertebrates

Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. For vertebrates, the Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we provide evidence that vertebrate SEPP1 Sec co...

Descripción completa

Detalles Bibliográficos
Autores principales: Penglase, Sam, Hamre, Kristin, Ellingsen, Ståle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Agricultural Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699779/
https://www.ncbi.nlm.nih.gov/pubmed/26734501
http://dx.doi.org/10.7717/peerj.1244
_version_ 1782408229810077696
author Penglase, Sam
Hamre, Kristin
Ellingsen, Ståle
author_facet Penglase, Sam
Hamre, Kristin
Ellingsen, Ståle
author_sort Penglase, Sam
collection PubMed
description Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. For vertebrates, the Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we provide evidence that vertebrate SEPP1 Sec content correlates positively with Se requirements. As the Se content of full length SEPP1 is genetically determined, this presents a unique case where a nutrient requirement can be predicted based on genomic sequence information.
format Online
Article
Text
id pubmed-4699779
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher PeerJ Inc.
record_format MEDLINE/PubMed
spelling pubmed-46997792016-01-05 The selenium content of SEPP1 versus selenium requirements in vertebrates Penglase, Sam Hamre, Kristin Ellingsen, Ståle PeerJ Agricultural Science Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. For vertebrates, the Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we provide evidence that vertebrate SEPP1 Sec content correlates positively with Se requirements. As the Se content of full length SEPP1 is genetically determined, this presents a unique case where a nutrient requirement can be predicted based on genomic sequence information. PeerJ Inc. 2015-09-10 /pmc/articles/PMC4699779/ /pubmed/26734501 http://dx.doi.org/10.7717/peerj.1244 Text en © 2015 Penglase et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Agricultural Science
Penglase, Sam
Hamre, Kristin
Ellingsen, Ståle
The selenium content of SEPP1 versus selenium requirements in vertebrates
title The selenium content of SEPP1 versus selenium requirements in vertebrates
title_full The selenium content of SEPP1 versus selenium requirements in vertebrates
title_fullStr The selenium content of SEPP1 versus selenium requirements in vertebrates
title_full_unstemmed The selenium content of SEPP1 versus selenium requirements in vertebrates
title_short The selenium content of SEPP1 versus selenium requirements in vertebrates
title_sort selenium content of sepp1 versus selenium requirements in vertebrates
topic Agricultural Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699779/
https://www.ncbi.nlm.nih.gov/pubmed/26734501
http://dx.doi.org/10.7717/peerj.1244
work_keys_str_mv AT penglasesam theseleniumcontentofsepp1versusseleniumrequirementsinvertebrates
AT hamrekristin theseleniumcontentofsepp1versusseleniumrequirementsinvertebrates
AT ellingsenstale theseleniumcontentofsepp1versusseleniumrequirementsinvertebrates
AT penglasesam seleniumcontentofsepp1versusseleniumrequirementsinvertebrates
AT hamrekristin seleniumcontentofsepp1versusseleniumrequirementsinvertebrates
AT ellingsenstale seleniumcontentofsepp1versusseleniumrequirementsinvertebrates

Ejemplares similares