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Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis

Epilepsy is a common neurological disorder with many causes. For temporal lobe epilepsy, antecedent insults are typically found. These risk factors include trauma or history of long fever-associated seizures (febrile status epilepticus) in childhood. Whereas the mechanisms by which such insults prom...

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Autores principales: Patterson, Katelin P., Brennan, Gary P., Curran, Megan, Kinney-Lang, Eli, Dubé, Celine, Rashid, Faisal, Ly, Catherine, Obenaus, Andre, Baram, Tallie Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699830/
https://www.ncbi.nlm.nih.gov/pubmed/26730400
http://dx.doi.org/10.1523/ENEURO.0034-15.2015
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author Patterson, Katelin P.
Brennan, Gary P.
Curran, Megan
Kinney-Lang, Eli
Dubé, Celine
Rashid, Faisal
Ly, Catherine
Obenaus, Andre
Baram, Tallie Z.
author_facet Patterson, Katelin P.
Brennan, Gary P.
Curran, Megan
Kinney-Lang, Eli
Dubé, Celine
Rashid, Faisal
Ly, Catherine
Obenaus, Andre
Baram, Tallie Z.
author_sort Patterson, Katelin P.
collection PubMed
description Epilepsy is a common neurological disorder with many causes. For temporal lobe epilepsy, antecedent insults are typically found. These risk factors include trauma or history of long fever-associated seizures (febrile status epilepticus) in childhood. Whereas the mechanisms by which such insults promote temporal lobe epilepsy are unknown, an extensive body of work has implicated inflammation and inflammatory mediators in both human and animal models of the disorder. However, direct evidence for an epileptogenic role for inflammation is lacking. Here we capitalized on a model where only a subgroup of insult-experiencing rodents develops epilepsy. We reasoned that if inflammation was important for generating epilepsy, then early inflammation should be more prominent in individuals destined to become epileptic compared with those that will not become epileptic. In addition, the molecular and temporal profile of inflammatory mediators would provide insights into which inflammatory pathways might be involved in the disease process. We examined inflammatory profiles in hippocampus and amygdala of individual rats and correlated them with a concurrent noninvasive, amygdalar magnetic resonance imaging epilepsy-predictive marker. We found significant individual variability in the expression of several important inflammatory mediators, but not in others. Of interest, a higher expression of a subset of hippocampal and amygdalar inflammatory markers within the first few hours following an insult correlated with the epilepsy-predictive signal. These findings suggest that some components of the inflammatory gene network might contribute to the process by which insults promote the development of temporal lobe epilepsy.
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spelling pubmed-46998302016-01-04 Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis Patterson, Katelin P. Brennan, Gary P. Curran, Megan Kinney-Lang, Eli Dubé, Celine Rashid, Faisal Ly, Catherine Obenaus, Andre Baram, Tallie Z. eNeuro New Research Epilepsy is a common neurological disorder with many causes. For temporal lobe epilepsy, antecedent insults are typically found. These risk factors include trauma or history of long fever-associated seizures (febrile status epilepticus) in childhood. Whereas the mechanisms by which such insults promote temporal lobe epilepsy are unknown, an extensive body of work has implicated inflammation and inflammatory mediators in both human and animal models of the disorder. However, direct evidence for an epileptogenic role for inflammation is lacking. Here we capitalized on a model where only a subgroup of insult-experiencing rodents develops epilepsy. We reasoned that if inflammation was important for generating epilepsy, then early inflammation should be more prominent in individuals destined to become epileptic compared with those that will not become epileptic. In addition, the molecular and temporal profile of inflammatory mediators would provide insights into which inflammatory pathways might be involved in the disease process. We examined inflammatory profiles in hippocampus and amygdala of individual rats and correlated them with a concurrent noninvasive, amygdalar magnetic resonance imaging epilepsy-predictive marker. We found significant individual variability in the expression of several important inflammatory mediators, but not in others. Of interest, a higher expression of a subset of hippocampal and amygdalar inflammatory markers within the first few hours following an insult correlated with the epilepsy-predictive signal. These findings suggest that some components of the inflammatory gene network might contribute to the process by which insults promote the development of temporal lobe epilepsy. Society for Neuroscience 2015-11-09 /pmc/articles/PMC4699830/ /pubmed/26730400 http://dx.doi.org/10.1523/ENEURO.0034-15.2015 Text en Copyright © 2015 Patterson et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Patterson, Katelin P.
Brennan, Gary P.
Curran, Megan
Kinney-Lang, Eli
Dubé, Celine
Rashid, Faisal
Ly, Catherine
Obenaus, Andre
Baram, Tallie Z.
Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis
title Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis
title_full Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis
title_fullStr Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis
title_full_unstemmed Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis
title_short Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis
title_sort rapid, coordinate inflammatory responses after experimental febrile status epilepticus: implications for epileptogenesis
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699830/
https://www.ncbi.nlm.nih.gov/pubmed/26730400
http://dx.doi.org/10.1523/ENEURO.0034-15.2015
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