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IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8(+) T Cells Responding to Persistent LCMV Infection

CD8(+) T cell exhaustion commonly occurs in chronic infections and cancers. During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deletion of antigen specific cells by apoptosis. A key...

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Detalles Bibliográficos
Autores principales:	Nayar, Ribhu, Schutten, Elizabeth, Jangalwe, Sonal, Durost, Philip A., Kenney, Laurie L., Conley, James M., Daniels, Keith, Brehm, Michael A., Welsh, Raymond M., Berg, Leslie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699851/ https://www.ncbi.nlm.nih.gov/pubmed/26714260 http://dx.doi.org/10.1371/journal.pone.0144826

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